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Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells

Overview of attention for article published in World Journal of Surgical Oncology, September 2012
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Title
Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells
Published in
World Journal of Surgical Oncology, September 2012
DOI 10.1186/1477-7819-10-200
Pubmed ID
Authors

Radhakrishnan Ganesh, Daniel JB Marks, Kevin Sales, Marc C Winslet, Alexander M Seifalian

Abstract

Arachidonic acid metabolite, generated by cyclooxygenase (COX), is implicated in the colorectal cancer (CRC) pathogenesis. Inhibiting COX may therefore have anti-carcinogenic effects. Results from use of non-steroidal anti-inflammatory drugs inhibiting only COX have been conflicting. It has been postulated that this might result from the shunting of arachidonic acid metabolism to the 5-lipoxygenase (5-LOX) pathway. Cancer cell viability is promoted by 5-LOX through several mechanisms that are similar to those of cyclooxygenase-2 (COX-2). Expression of 5-LOX is upregulated in colorectal adenoma and cancer. The aim of this study was to investigate the shunting of arachidonic acid metabolism to the 5-LOX pathway by cyclooxygenase inhibition and to determine if this process antagonizes the anti-cancer effect in colorectal cancer cells.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 21%
Researcher 6 14%
Student > Bachelor 5 12%
Student > Doctoral Student 4 10%
Other 3 7%
Other 6 14%
Unknown 9 21%
Readers by discipline Count As %
Medicine and Dentistry 13 31%
Agricultural and Biological Sciences 6 14%
Biochemistry, Genetics and Molecular Biology 4 10%
Chemistry 4 10%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Other 2 5%
Unknown 10 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2012.
All research outputs
#18,316,001
of 22,679,690 outputs
Outputs from World Journal of Surgical Oncology
#1,020
of 2,038 outputs
Outputs of similar age
#130,376
of 171,749 outputs
Outputs of similar age from World Journal of Surgical Oncology
#26
of 70 outputs
Altmetric has tracked 22,679,690 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,038 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 171,749 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.