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Low nuclear body formation and tax SUMOylation do not prevent NF-kappaB promoter activation

Overview of attention for article published in Retrovirology, September 2012
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Title
Low nuclear body formation and tax SUMOylation do not prevent NF-kappaB promoter activation
Published in
Retrovirology, September 2012
DOI 10.1186/1742-4690-9-77
Pubmed ID
Authors

Amandine Bonnet, Voahangy Randrianarison-Huetz, Patrycja Nzounza, Martine Nedelec, Maxime Chazal, Laetitia Waast, Sabrina Pene, Ali Bazarbachi, Renaud Mahieux, Laurence Bénit, Claudine Pique

Abstract

The Tax protein encoded by Human T-lymphotropic virus type 1 (HTLV-1) is a powerful activator of the NF-κB pathway, a property critical for HTLV-1-induced immortalization of CD4⁺ T lymphocytes. Tax permanently stimulates this pathway at a cytoplasmic level by activating the IκB kinase (IKK) complex and at a nuclear level by enhancing the binding of the NF-κB factor RelA to its cognate promoters and by forming nuclear bodies, believed to represent transcriptionally active structures. In previous studies, we reported that Tax ubiquitination and SUMOylation play a critical role in Tax localization and NF-κB activation. Indeed, analysis of lysine Tax mutants fused or not to ubiquitin or SUMO led us to propose a two-step model in which Tax ubiquitination first intervenes to activate IKK while Tax SUMOylation is subsequently required for promoter activation within Tax nuclear bodies. However, recent studies showing that ubiquitin or SUMO can modulate Tax activities in either the nucleus or the cytoplasm and that SUMOylated Tax can serve as substrate for ubiquitination suggested that Tax ubiquitination and SUMOylation may mediate redundant rather than successive functions.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 42%
Student > Master 3 16%
Student > Ph. D. Student 3 16%
Other 1 5%
Student > Doctoral Student 1 5%
Other 2 11%
Unknown 1 5%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 26%
Agricultural and Biological Sciences 4 21%
Pharmacology, Toxicology and Pharmaceutical Science 2 11%
Immunology and Microbiology 2 11%
Business, Management and Accounting 1 5%
Other 3 16%
Unknown 2 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2012.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Retrovirology
#1,079
of 1,273 outputs
Outputs of similar age
#148,842
of 190,777 outputs
Outputs of similar age from Retrovirology
#44
of 61 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.