Title |
Eukaryotic genomes may exhibit up to 10 generic classes of gene promoters
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Published in |
BMC Genomics, September 2012
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DOI | 10.1186/1471-2164-13-512 |
Pubmed ID | |
Authors |
Paul Gagniuc, Constantin Ionescu-Tirgoviste |
Abstract |
The main function of gene promoters appears to be the integration of different gene products in their biological pathways in order to maintain homeostasis. Generally, promoters have been classified in two major classes, namely TATA and CpG. Nevertheless, many genes using the same combinatorial formation of transcription factors have different gene expression patterns. Accordingly, we tried to ask ourselves some fundamental questions: Why certain genes have an overall predisposition for higher gene expression levels than others? What causes such a predisposition? Is there a structural relationship of these sequences in different tissues? Is there a strong phylogenetic relationship between promoters of closely related species? |
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