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A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression

Overview of attention for article published in Molecular Cancer, November 2015
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Title
A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression
Published in
Molecular Cancer, November 2015
DOI 10.1186/s12943-015-0454-6
Pubmed ID
Authors

Haiyang Chen, Liang Hu, Zaili Luo, Jian Zhang, Cunzhen Zhang, Bijun Qiu, Liwei Dong, Yexiong Tan, Jin Ding, Shanhua Tang, Feng Shen, Zhong Li, Hongyang Wang

Abstract

Aberrant expression of A20 has been reported in several human malignancies including hepatocellular carcinoma (HCC). However, its clinical relevance and potential role in HCC remain unknown. Quantitative PCR, Western blots and immunohistochemistry analyses were used to quantify A20 expression in HCC samples and cell lines. The correlation of A20 expression with clinicopathologic features was analyzed in a cohort containing 143 patients with primary HCC. Kaplan-Meier curves were used to evaluate the association between A20 expression and patient survival. Functional studies were performed to determine the effects of A20 on proliferation and metastasis of HCC cells in vitro and in vivo. Expression of A20 was increased in HCC tissues and cell lines. Increased expression of A20 was negatively correlated with the tumor size, TNM stage, tumor thrombus formation, capsular invasion and serum AFP levels. Patients with higher A20 expression had a prolonged disease-free survival and overall survival than those with lower A20 expression. Forced expression of A20 significantly inhibited the proliferative and invasive properties of HCC cells both in vitro and in vivo, whereas knockdown of A20 expression showed the opposite effects. Further studies revealed that expression of A20 was inversely correlated with Twist1 levels and NF-κB activity in HCC tissues and cell lines. A20-induced suppression of proliferation and migration of HCC cells were mainly mediated through inhibition of Twist1 expression that was regulated at least partly by A20-induced attenuation of NF-κB activity. Our results demonstrate that A20 plays a negative role in the development and progression of HCC probably through inhibiting Twist1 expression. A20 may serve as a novel prognostic biomarker and potential therapeutic target for HCC patients.

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Mendeley readers

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The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 11%
Researcher 2 11%
Student > Ph. D. Student 2 11%
Unspecified 1 6%
Other 1 6%
Other 2 11%
Unknown 8 44%
Readers by discipline Count As %
Medicine and Dentistry 3 17%
Biochemistry, Genetics and Molecular Biology 3 17%
Agricultural and Biological Sciences 2 11%
Chemistry 1 6%
Unspecified 1 6%
Other 0 0%
Unknown 8 44%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2016.
All research outputs
#20,335,770
of 22,880,691 outputs
Outputs from Molecular Cancer
#1,484
of 1,725 outputs
Outputs of similar age
#239,202
of 285,407 outputs
Outputs of similar age from Molecular Cancer
#32
of 37 outputs
Altmetric has tracked 22,880,691 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,725 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.