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Shared genetic variants between serum levels of high-density lipoprotein cholesterol and wheezing in a cohort of children from Cyprus

Overview of attention for article published in Italian Journal of Pediatrics, January 2016
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Title
Shared genetic variants between serum levels of high-density lipoprotein cholesterol and wheezing in a cohort of children from Cyprus
Published in
Italian Journal of Pediatrics, January 2016
DOI 10.1186/s13052-016-0276-1
Pubmed ID
Authors

Yiallouros, Panayiotis K, Kouis, Panayiotis, Kolokotroni, Ourania, Youhanna, Sonia, Savva, Savvas C, Dima, Kleanthi, Zerva, Aikaterini, Platt, Danielle, Middleton, Nicos, Zalloua, Pierre, Panayiotis K. Yiallouros, Panayiotis Kouis, Ourania Kolokotroni, Sonia Youhanna, Savvas C. Savva, Kleanthi Dima, Aikaterini Zerva, Danielle Platt, Nicos Middleton, Pierre Zalloua

Abstract

In a cohort of children in Cyprus, we recently reported low levels of high density lipoprotein cholesterol (HDL-C) to be associated with asthma. We examined whether genetic polymorphisms that were previously linked individually to asthma, obesity, or HDL-C are associated with both asthma and HDL-C levels in the Cyprus cohort. We assessed genotypes frequencies in current-wheezers (n = 190) and non-asthmatic controls (n = 671) and HDL-C levels across several genotypes. Binary logistic regression models were used to assess the effect of genotypes on wheezing risk and examined whether this effect is carried out through changes of HDL-C. Of the 16 polymorphisms tested, two polymorphisms TNFa rs3093664 and PRKCA rs9892651 presented significant differences in genotype distribution among current-wheezers and controls. Higher HDL-C levels were noted in carriers of genotype GG of polymorphism TNFa rs3093664 that was protective for wheezing Vs AG and AA genotypes (65.3 Vs 51.8 and 53.3 mg/dl, p-value < 0.001 and p-value for trend = 0.028). In polymorphism PRKCA rs9892651, HDL-C levels were lower in carriers of CC and TC genotypes that were more frequent in current-wheezers Vs TT genotype (52.2 and 52.7 Vs 55.2 mg/dl, p-value = 0.042 and p-value for trend = 0.02). The association of TNFa rs3093664 with wheezing is partly mediated by its effect on HDL-C whereas association of PRKCA rs9892651 with wheezing appeared to be independent of HDL-C. We found evidence that two SNPs located in different genetic loci, are associated with both wheezing and HDL-C levels, although more studies in other populations are needed to confirm our results.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 15%
Researcher 2 15%
Student > Ph. D. Student 1 8%
Other 1 8%
Professor 1 8%
Other 1 8%
Unknown 5 38%
Readers by discipline Count As %
Medicine and Dentistry 3 23%
Nursing and Health Professions 3 23%
Biochemistry, Genetics and Molecular Biology 2 15%
Unknown 5 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2017.
All research outputs
#10,100,371
of 11,389,380 outputs
Outputs from Italian Journal of Pediatrics
#296
of 401 outputs
Outputs of similar age
#220,552
of 266,937 outputs
Outputs of similar age from Italian Journal of Pediatrics
#10
of 11 outputs
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