Title |
Heritable patterns of tooth decay in the permanent dentition: principal components and factor analyses
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Published in |
BMC Oral Health, March 2012
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DOI | 10.1186/1472-6831-12-7 |
Pubmed ID | |
Authors |
John R Shaffer, Eleanor Feingold, Xiaojing Wang, Karen TCuenco, Daniel E Weeks, Rebecca S DeSensi, Deborah E Polk, Steve Wendell, Robert J Weyant, Richard Crout, Daniel W McNeil, Mary L Marazita |
Abstract |
Dental caries is the result of a complex interplay among environmental, behavioral, and genetic factors, with distinct patterns of decay likely due to specific etiologies. Therefore, global measures of decay, such as the DMFS index, may not be optimal for identifying risk factors that manifest as specific decay patterns, especially if the risk factors such as genetic susceptibility loci have small individual effects. We used two methods to extract patterns of decay from surface-level caries data in order to generate novel phenotypes with which to explore the genetic regulation of caries. |
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Geographical breakdown
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Demographic breakdown
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