Title |
A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone
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Published in |
BMC Cancer, April 2011
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DOI | 10.1186/1471-2407-11-149 |
Pubmed ID | |
Authors |
Jeffrey D Altenburg, Andrew A Bieberich, Colin Terry, Kevin A Harvey, Justin F VanHorn, Zhidong Xu, V Jo Davisson, Rafat A Siddiqui |
Abstract |
Breast cancer is a collection of diseases in which molecular phenotypes can act as both indicators and mediators of therapeutic strategy. Therefore, candidate therapeutics must be assessed in the context of multiple cell lines with known molecular phenotypes. Docosahexaenoic acid (DHA) and curcumin (CCM) are dietary compounds known to antagonize breast cancer cell proliferation. We report that these compounds in combination exert a variable antiproliferative effect across multiple breast cell lines, which is synergistic in SK-BR-3 cells and triggers cell signaling events not predicted by the activity of either compound alone. |
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Mexico | 1 | 17% |
Australia | 1 | 17% |
Bahrain | 1 | 17% |
Venezuela, Bolivarian Republic of | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 67% |
Practitioners (doctors, other healthcare professionals) | 2 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 100 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 17% |
Student > Bachelor | 15 | 15% |
Researcher | 10 | 10% |
Student > Master | 9 | 9% |
Student > Doctoral Student | 6 | 6% |
Other | 27 | 26% |
Unknown | 18 | 18% |
Readers by discipline | Count | As % |
---|---|---|
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Pharmacology, Toxicology and Pharmaceutical Science | 9 | 9% |
Medicine and Dentistry | 8 | 8% |
Biochemistry, Genetics and Molecular Biology | 8 | 8% |
Engineering | 6 | 6% |
Other | 13 | 13% |
Unknown | 26 | 25% |