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The role of atorvastatin on the restenosis process post-PTA in a diabetic rabbit model

Overview of attention for article published in BMC Cardiovascular Disorders, July 2016
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Title
The role of atorvastatin on the restenosis process post-PTA in a diabetic rabbit model
Published in
BMC Cardiovascular Disorders, July 2016
DOI 10.1186/s12872-016-0324-1
Pubmed ID
Authors

Xiaojun Zhou, Yaru Mou, Xue Shen, Tianshu Yang, Ju Liu, Fupeng Liu, Jianjun Dong, Lin Liao

Abstract

Restenosis remains to be a major limitation of percutaneous transluminal angioplasty (PTA) for diabetic patients with peripheral vascular disease (PVD). Despite of stations routine implements to prevent such progress, its exact effect is unclear. In our study, balloon was successfully implanted in the iliac artery of atherosclerotic rabbit. Patency of the narrowed artery was interrogated using ultrasound. Atorvastatin or vehicle was administered orally to rabbits from day 0 to day 28 after double-injury surgery. On day 7, day 14, and day 28, restenotic arteries were harvested and processed for histopathlogical analysis. Our data show that, after double-injury surgery, the intima was composed mostly by SMCs at all time course in rabbits undergoing surgery process. Significant increases in stenosis rates were noted from day 7 to day 14 (from 21 ± 5.85 % to 60.93 ± 12.46 %). On day 28 after double-injury surgery, severe restenosis was observed and daily administration of atorvastatin cannot prevent restenosis' formation (88.69 ± 3.71 % vs. 90.02 ± 3.11 %, P > 0.05). The PCNA index and SMCs proliferation were correlated with the scores of the vascular pathology. Our results indicate that double-injury model can mimic clinical restenosis, based on this model, atorvastatin showed no therapeutic effect on restenosis process in diabetic rabbits after PTA.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 8%
Unknown 11 92%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 33%
Student > Postgraduate 2 17%
Researcher 1 8%
Unspecified 1 8%
Lecturer 1 8%
Other 0 0%
Unknown 3 25%
Readers by discipline Count As %
Medicine and Dentistry 3 25%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Unspecified 1 8%
Linguistics 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Other 0 0%
Unknown 5 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2016.
All research outputs
#18,465,988
of 22,880,691 outputs
Outputs from BMC Cardiovascular Disorders
#1,117
of 1,618 outputs
Outputs of similar age
#273,233
of 356,439 outputs
Outputs of similar age from BMC Cardiovascular Disorders
#13
of 24 outputs
Altmetric has tracked 22,880,691 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,618 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 356,439 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.