↓ Skip to main content

Optimal MHC-II-restricted tumor antigen presentation to CD4+ T helper cells: the key issue for development of anti-tumor vaccines

Overview of attention for article published in Journal of Translational Medicine, July 2012
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

twitter
2 tweeters
patent
1 patent

Citations

dimensions_citation
26 Dimensions

Readers on

mendeley
30 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Optimal MHC-II-restricted tumor antigen presentation to CD4+ T helper cells: the key issue for development of anti-tumor vaccines
Published in
Journal of Translational Medicine, July 2012
DOI 10.1186/1479-5876-10-154
Pubmed ID
Authors

Roberto S Accolla, Giovanna Tosi

Abstract

Present immunoprevention and immunotherapeutic approaches against cancer suffer from the limitation of being not "sterilizing" procedures, as very poor protection against the tumor is obtained. Thus newly conceived anti-tumor vaccination strategies are urgently needed. In this review we will focus on ways to provide optimal MHC class II-restricted tumor antigen presentation to CD4+ T helper cells as a crucial parameter to get optimal and protective adaptive immune response against tumor. Through the description of successful preventive or therapeutic experimental approaches to vaccinate the host against the tumor we will show that optimal activation of MHC class II-restricted tumor specific CD4+ T helper cells can be achieved in various ways. Interestingly, the success in tumor eradication and/or growth arrest generated by classical therapies such as radiotherapy and chemotherapy in some instances can be re-interpreted on the basis of an adaptive immune response induced by providing suitable access of tumor-associated antigens to MHC class II molecules. Therefore, focussing on strategies to generate better and suitable MHC class II-restricted activation of tumor specific CD4+ T helper cells may have an important impact on fighting and defeating cancer.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 23%
Student > Ph. D. Student 6 20%
Student > Master 4 13%
Student > Bachelor 4 13%
Professor 3 10%
Other 2 7%
Unknown 4 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 30%
Medicine and Dentistry 5 17%
Biochemistry, Genetics and Molecular Biology 4 13%
Immunology and Microbiology 2 7%
Chemistry 2 7%
Other 2 7%
Unknown 6 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2016.
All research outputs
#4,666,639
of 17,358,590 outputs
Outputs from Journal of Translational Medicine
#682
of 3,205 outputs
Outputs of similar age
#35,287
of 142,749 outputs
Outputs of similar age from Journal of Translational Medicine
#2
of 11 outputs
Altmetric has tracked 17,358,590 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,205 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 142,749 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.