Title |
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
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Published in |
Molecular Brain, October 2012
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DOI | 10.1186/1756-6606-5-35 |
Pubmed ID | |
Authors |
Yoichi Imaizumi, Yohei Okada, Wado Akamatsu, Masato Koike, Naoko Kuzumaki, Hideki Hayakawa, Tomoko Nihira, Tetsuro Kobayashi, Manabu Ohyama, Shigeto Sato, Masashi Takanashi, Manabu Funayama, Akiyoshi Hirayama, Tomoyoshi Soga, Takako Hishiki, Makoto Suematsu, Takuya Yagi, Daisuke Ito, Arifumi Kosakai, Kozo Hayashi, Masanobu Shouji, Atsushi Nakanishi, Norihiro Suzuki, Yoshikuni Mizuno, Noboru Mizushima, Masayuki Amagai, Yasuo Uchiyama, Hideki Mochizuki, Nobutaka Hattori, Hideyuki Okano |
Abstract |
Parkinson's disease (PD) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra (SN). The familial form of PD, PARK2, is caused by mutations in the parkin gene. parkin-knockout mouse models show some abnormalities, but they do not fully recapitulate the pathophysiology of human PARK2. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 20% |
Australia | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Scientists | 1 | 20% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 1% |
Brazil | 2 | <1% |
Switzerland | 1 | <1% |
Germany | 1 | <1% |
Unknown | 304 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 68 | 22% |
Researcher | 57 | 18% |
Student > Master | 42 | 13% |
Student > Bachelor | 37 | 12% |
Other | 16 | 5% |
Other | 49 | 16% |
Unknown | 43 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 73 | 23% |
Neuroscience | 67 | 21% |
Biochemistry, Genetics and Molecular Biology | 45 | 14% |
Medicine and Dentistry | 41 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 4% |
Other | 21 | 7% |
Unknown | 54 | 17% |