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Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

Overview of attention for article published in Molecular Brain, October 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

blogs
1 blog
twitter
5 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
295 Dimensions

Readers on

mendeley
293 Mendeley
citeulike
1 CiteULike
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Title
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
Published in
Molecular Brain, October 2012
DOI 10.1186/1756-6606-5-35
Pubmed ID
Authors

Yoichi Imaizumi, Yohei Okada, Wado Akamatsu, Masato Koike, Naoko Kuzumaki, Hideki Hayakawa, Tomoko Nihira, Tetsuro Kobayashi, Manabu Ohyama, Shigeto Sato, Masashi Takanashi, Manabu Funayama, Akiyoshi Hirayama, Tomoyoshi Soga, Takako Hishiki, Makoto Suematsu, Takuya Yagi, Daisuke Ito, Arifumi Kosakai, Kozo Hayashi, Masanobu Shouji, Atsushi Nakanishi, Norihiro Suzuki, Yoshikuni Mizuno, Noboru Mizushima, Masayuki Amagai, Yasuo Uchiyama, Hideki Mochizuki, Nobutaka Hattori, Hideyuki Okano

Abstract

Parkinson's disease (PD) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra (SN). The familial form of PD, PARK2, is caused by mutations in the parkin gene. parkin-knockout mouse models show some abnormalities, but they do not fully recapitulate the pathophysiology of human PARK2.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 293 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 1%
Brazil 2 <1%
Switzerland 1 <1%
Germany 1 <1%
Unknown 285 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 67 23%
Researcher 55 19%
Student > Master 42 14%
Student > Bachelor 38 13%
Other 15 5%
Other 48 16%
Unknown 28 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 73 25%
Neuroscience 66 23%
Biochemistry, Genetics and Molecular Biology 43 15%
Medicine and Dentistry 41 14%
Pharmacology, Toxicology and Pharmaceutical Science 11 4%
Other 20 7%
Unknown 39 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2012.
All research outputs
#2,217,110
of 18,796,975 outputs
Outputs from Molecular Brain
#98
of 961 outputs
Outputs of similar age
#16,130
of 147,582 outputs
Outputs of similar age from Molecular Brain
#1
of 8 outputs
Altmetric has tracked 18,796,975 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 961 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 147,582 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them