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Effects of teriparatide on cementless bipolar hemiarthroplasty in patients with osteoporotic femoral neck fractures

Overview of attention for article published in BMC Musculoskeletal Disorders, July 2016
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Title
Effects of teriparatide on cementless bipolar hemiarthroplasty in patients with osteoporotic femoral neck fractures
Published in
BMC Musculoskeletal Disorders, July 2016
DOI 10.1186/s12891-016-1149-x
Pubmed ID
Authors

Tsan-Wen Huang, Kuo-Chin Huang, Shih-Jie Lin, Po-Yao Chuang, Hsin-Nung Shih, Mel S. Lee, Robert Wen-Wei Hsu, Wun-Jer Shen

Abstract

For osteoporotic femoral neck fractures, suitable bone-implant stability is critical for pain relief, early return to daily activities and reduction of complications. Teriparatide (parathyroid hormone [PTH1-34]) can improve bone-implant stability in some basic studies. However it's use in osteoporotic femoral neck fractures treated by cementless hemiarthroplasties for the beneficial effects on bone-implant stability is sparse in the literature. The aim of this study was to determine if post-operative teriparatide administration can reduce femoral stem migration and improve early functional recovery and health-related quality of life (HRQoL). Between 2010 and 2014, patients with osteoporotic femoral neck fracture who underwent cementless bipolar hemiarthroplasty were included into this retrospective cohort study. Group A included patients treated with cementless bipolar hemiarthroplasty only; Group B patients had additional teriparatide. Demographic data, complications, radiographic and functional outcomes as well as health-related quality of life (HRQoL) were compared. There were 52 hips in group A (no teriparatide) and 40 hips in group B (patient who received teriparatide). The subsidence of the femoral stem tended to be significantly decreased in the teriparatide group at 6 and 12 weeks post-operatively (p = 0.003 and p = 0.008, respectively). The Harris Hip Score (HHS) increased significantly from pre-operation to 6 weeks post-operatively and thereafter up to one year in both groups. However, there were no significant differences in terms of subsequent fracture, mortality, HHS, and HRQoL between two groups during the entire study period. Teriparatide significantly reduces the subsidence of the cementless femoral stem in elderly patients in the early post-operative period, but this benefit does not reflect better functional outcomes and HRQoL. Further prospective randomized large-scale cohort study is warranted for evidence-based recommendations.

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Mendeley readers

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The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 64 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 16%
Student > Master 6 9%
Other 5 8%
Researcher 5 8%
Student > Postgraduate 4 6%
Other 11 17%
Unknown 23 36%
Readers by discipline Count As %
Medicine and Dentistry 26 41%
Nursing and Health Professions 6 9%
Arts and Humanities 2 3%
Social Sciences 2 3%
Business, Management and Accounting 1 2%
Other 6 9%
Unknown 21 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2016.
All research outputs
#15,380,359
of 22,881,154 outputs
Outputs from BMC Musculoskeletal Disorders
#2,459
of 4,055 outputs
Outputs of similar age
#233,757
of 363,105 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#55
of 81 outputs
Altmetric has tracked 22,881,154 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,055 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 363,105 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.