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RNA expression of TLR10 in normal equine tissues

Overview of attention for article published in BMC Research Notes, July 2016
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  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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Title
RNA expression of TLR10 in normal equine tissues
Published in
BMC Research Notes, July 2016
DOI 10.1186/s13104-016-2161-9
Pubmed ID
Authors

Rachael E. Tarlinton, Lauren Alder, Joanna Moreton, Grazieli Maboni, Richard D. Emes, Sabine Tötemeyer

Abstract

Toll like receptors are one of the major innate immune system pathogen recognition systems. There is little data on the expression of the TLR10 member of this family in the horse. This paper describes the genetic structure of the Equine TLR10 gene and its RNA expression in a range of horse tissues. It describes the phylogenetic analysis of the Equine TLR1,6,10,2 annotations in the horse genome, firmly identifying them in their corresponding gene clades compared to other species and firmly placing the horse gene with other TLR10 genes from odd-toed ungulates. Additional 3' transcript extensions to that annotated for TLR10 in the horse genome have been identified by analysis of RNAseq data. RNA expression of the equine TLR10 gene was highest in peripheral blood mononucleocytes and lymphoid tissue (lymph nodes and spleen), however some expression was detected in all tissues tested (jejunum, caudal mesenteric lymph nodes, bronchial lymph node, spleen, lung, colon, kidney and liver). Additional data on RNAseq expression of all equine TLR genes (1-4 and 6-10) demonstrate higher expression of TLR4 than other equine TLRs in all tissues. The equine TLR10 gene displays significant homology to other mammalian TLR10 genes and could be reasonably assumed to have similar fuctions. Its RNA level expression is higher in resting state PBMCs in horses than in other tissues.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 22%
Professor 2 11%
Student > Ph. D. Student 2 11%
Student > Bachelor 1 6%
Lecturer 1 6%
Other 1 6%
Unknown 7 39%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 3 17%
Immunology and Microbiology 3 17%
Agricultural and Biological Sciences 3 17%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 0 0%
Unknown 7 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2016.
All research outputs
#7,240,909
of 22,881,154 outputs
Outputs from BMC Research Notes
#1,167
of 4,269 outputs
Outputs of similar age
#123,212
of 363,105 outputs
Outputs of similar age from BMC Research Notes
#30
of 86 outputs
Altmetric has tracked 22,881,154 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,269 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 363,105 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.