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X Demographics
Mendeley readers
| Title |
Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial
|
|---|---|
| Published in |
Trials, September 2012
|
| DOI | 10.1186/1745-6215-13-168 |
| Pubmed ID | |
| Authors |
Matthew R Sydes, Mahesh KB Parmar, Malcolm D Mason, Noel W Clarke, Claire Amos, John Anderson, Johann de Bono, David P Dearnaley, John Dwyer, Charlene Green, Gordana Jovic, Alastair WS Ritchie, J Martin Russell, Karen Sanders, George Thalmann, Nicholas D James |
| Abstract |
Systemic Therapy for Advanced or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) is a randomized controlled trial that follows a novel multi-arm, multi-stage (MAMS) design. We describe methodological and practical issues arising with (1) stopping recruitment to research arms following a pre-planned intermediate analysis and (2) adding a new research arm during the trial. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 14 | 61% |
| India | 2 | 9% |
| United States | 1 | 4% |
| Spain | 1 | 4% |
| Unknown | 5 | 22% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 57% |
| Practitioners (doctors, other healthcare professionals) | 6 | 26% |
| Scientists | 4 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| United States | 1 | <1% |
| China | 1 | <1% |
| Unknown | 139 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 38 | 26% |
| Student > Ph. D. Student | 17 | 12% |
| Student > Master | 16 | 11% |
| Professor | 9 | 6% |
| Other | 9 | 6% |
| Other | 25 | 17% |
| Unknown | 30 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 54 | 38% |
| Mathematics | 8 | 6% |
| Psychology | 6 | 4% |
| Agricultural and Biological Sciences | 4 | 3% |
| Biochemistry, Genetics and Molecular Biology | 4 | 3% |
| Other | 17 | 12% |
| Unknown | 51 | 35% |