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Minimum inhibitory concentration of vancomycin to methicillin resistant Staphylococcus aureus isolated from different clinical samples at a tertiary care hospital in Nepal

Overview of attention for article published in Antimicrobial Resistance & Infection Control, July 2016
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Title
Minimum inhibitory concentration of vancomycin to methicillin resistant Staphylococcus aureus isolated from different clinical samples at a tertiary care hospital in Nepal
Published in
Antimicrobial Resistance & Infection Control, July 2016
DOI 10.1186/s13756-016-0126-3
Pubmed ID
Authors

Arjun Ojha Kshetry, Narayan Dutt Pant, Raju Bhandari, Sabita Khatri, Krishma Laxmi Shrestha, Shambhu Kumar Upadhaya, Asia Poudel, Binod Lekhak, Bijendra R. Raghubanshi

Abstract

Methicillin resistant Staphylococcus aureus (MRSA) has evolved as a serious threat to public health. It has capability to cause infections not only in health care settings but also in community. Due to the multidrug resistance shown by MRSA, there are limited treatment options for the infections caused by this superbug. Vancomycin is used as the drug of choice for the treatment of infections caused by MRSA. Different studies from all around the world have documented the emergence of strains of S. aureus those are intermediate sensitive or resistant to vancomycin. And recently, there have been reports of reduced susceptibility of MRSA to vancomycin, from Nepal also. So the main purpose of this study was to determine the minimum inhibitory concentration (MIC) of vancomycin to methicillin resistant S. aureus isolated from different clinical specimens. Total 125 strains of S. aureus isolated from different clinical samples at KIST Medical College and Teaching Hospital, Lalitpur, Nepal from Nov 2012 to June 2013, were subjected to MRSA detection by cefoxitin disc diffusion method. The minimum inhibitory concentrations of vancomycin to confirmed MRSA strains were determined by agar dilution method. Yellow colored colonies in mannitol salt agar, which were gram positive cocci, catalase positive and coagulase positive were confirmed to be S. aureus. Among, total 125 S. aureus strains isolated; 47(37.6%) were MRSA. Minimum inhibitory concentrations of vancomycin to the strains of MRSA ranged from 0.125 μg/ml to 1 μg/ml. From our findings we concluded that the rate of isolation of MRSA among all the strains of S. aureus isolated from clinical samples was very high. However, none of the MRSA strains were found to be vancomycin intermediate-sensitive or vancomycin-resistant.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 113 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 20 18%
Student > Master 17 15%
Student > Ph. D. Student 10 9%
Student > Postgraduate 9 8%
Student > Doctoral Student 6 5%
Other 20 18%
Unknown 31 27%
Readers by discipline Count As %
Immunology and Microbiology 26 23%
Biochemistry, Genetics and Molecular Biology 13 12%
Medicine and Dentistry 12 11%
Agricultural and Biological Sciences 8 7%
Pharmacology, Toxicology and Pharmaceutical Science 8 7%
Other 13 12%
Unknown 33 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2016.
All research outputs
#14,281,005
of 24,003,070 outputs
Outputs from Antimicrobial Resistance & Infection Control
#867
of 1,347 outputs
Outputs of similar age
#204,857
of 370,379 outputs
Outputs of similar age from Antimicrobial Resistance & Infection Control
#3
of 5 outputs
Altmetric has tracked 24,003,070 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,347 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 370,379 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.