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Long-term outcome after bilateral lung transplantation – a retrospective study from a low-volume center experience

Overview of attention for article published in BMC Surgery, March 2015
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Title
Long-term outcome after bilateral lung transplantation – a retrospective study from a low-volume center experience
Published in
BMC Surgery, March 2015
DOI 10.1186/s12893-015-0010-8
Pubmed ID
Authors

Shun-Mao Yang, Shu-Chien Huang, Shuenn-Wen Kuo, Pei-Ming Huang, Sung-Ching Pan, Jang-Ming Lee, Hong-Shiee Lai, Hsao-Hsun Hsu

Abstract

The aim of this study is to review the long-term outcomes of bilateral lung transplantation (BLTx) in our institution and examine the potential issues that may influence outcomes in a low-volume center. A retrospective review of BLTx performed in our institution between July 2006 and December 2012 was conducted. Standardized donor selection, procurement, and preservation protocols for brain-dead donors were applied. Measured outcomes were in-hospital mortality and actuarial survival using the Kaplan-Meier method. Twenty-five consecutive patients (13 male, 12 female) underwent BLTx with a mean age of 41.8 ± 13.5 years. Before LTx, the mean body mass index was 18.3 ± 3.1 kg/m2. Seven of these patients (28%) required oxygen supplementation at rest before LTx, while the remaining patients (72%) required noninvasive mechanical ventilation (n = 6, 24%), invasive mechanical ventilation (n = 9, 36%) or extracorporeal membrane oxygenation (ECMO) (n = 3, 12%). The lung grafts were procured from brain-dead donors with the mean age of 26.8 ± 11.4 year and the best PaO2 / FiO2 ratio of 513 ± 77 before procurement. All cross match results between same-race donors and recipients were negative. The percentage of same-sex matching and CMV mismatching were 64% and 4%, respectively. The mean time listed on the transplant list was 308 ± 261 days. The mean ischemic time for the first and second grafts were 222 ± 62 and 361 ± 67 minutes. During transplantation, 22 (88%) patients depended on ECMO and one (4%) on cardiopulmonary bypass support. All but two patients (82%) were discharged home in good condition; two (8%) patients died within 3 months after BLTx. The cumulative survival rates at 1-, 2-, 3-, and 5-years were 88%, 83%, 72%, and 72%, respectively. Although the comparatively few annual LTx performed is consistent with the low donation rate, our single-center growing experience demonstrates that good post-lung transplant outcomes can be achieved at a low-volume LTx center.

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Mendeley readers

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The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 27%
Student > Bachelor 2 18%
Professor > Associate Professor 2 18%
Student > Master 1 9%
Student > Ph. D. Student 1 9%
Other 1 9%
Unknown 1 9%
Readers by discipline Count As %
Medicine and Dentistry 6 55%
Pharmacology, Toxicology and Pharmaceutical Science 1 9%
Immunology and Microbiology 1 9%
Nursing and Health Professions 1 9%
Unknown 2 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2016.
All research outputs
#20,336,031
of 22,881,154 outputs
Outputs from BMC Surgery
#882
of 1,322 outputs
Outputs of similar age
#242,247
of 286,082 outputs
Outputs of similar age from BMC Surgery
#22
of 25 outputs
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