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Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma

Overview of attention for article published in Clinical Epigenetics, July 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)

Mentioned by

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5 tweeters

Citations

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22 Dimensions

Readers on

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33 Mendeley
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Title
Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma
Published in
Clinical Epigenetics, July 2016
DOI 10.1186/s13148-016-0243-0
Pubmed ID
Authors

Pierre L. Triozzi, Susan Achberger, Wayne Aldrich, John W. Crabb, Yogen Saunthararajah, Arun D. Singh

Abstract

Epigenetic events mediated by methylation and histone modifications have been associated with the development of metastasis in patients with uveal melanoma. The role of epigenetic events mediated by microRNA (miR) is less clear. Tumor and plasma miR expression was examined in patients with primary uveal melanoma with tumor monosomy-3, a predictor of metastasis. miR profiling of tumors by microarray found six miRs over-expressed and 19 under-expressed in 33 tumors with monosomy-3 compared to 22 without. None of the miRs differentially expressed in tumors with and without monosomy-3 was differentially expressed in tumors with and without tumor infiltrating lymphocytes. Tumors manifesting monosomy-3 were also characterized by higher levels of TARBP2 and DDX17 and by lower levels of XPO5 and HIWI, miR biogenesis factors. miR profiling of plasma by a quantitative nuclease protection assay found elevated levels of 11 miRs and reduction in four in patients with tumor monosomy-3. Only three miRs differentially expressed in the tumor arrays were detectable in plasma. miRs implicated in uveal melanoma development were not differentially expressed. Elevated plasma levels in patients with tumor monosomy-3 of miR-92b, identified in the tumor array, and of miR-199-5p and miR-223, identified in the plasma array, were confirmed by quantitative real-time polymerase chain reaction. Levels were also higher in patients compared to normal controls. These results support a role for epigenetic mechanisms in the development of metastasis in patients with uveal melanoma and the analysis of miRs as biomarkers of metastatic risk. They also suggest that potentially useful blood miRs may be derived from the host response as well as the tumor.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 24%
Researcher 7 21%
Student > Master 5 15%
Student > Bachelor 3 9%
Other 2 6%
Other 3 9%
Unknown 5 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 33%
Medicine and Dentistry 9 27%
Agricultural and Biological Sciences 5 15%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Neuroscience 1 3%
Other 0 0%
Unknown 6 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2016.
All research outputs
#8,768,665
of 16,530,799 outputs
Outputs from Clinical Epigenetics
#439
of 885 outputs
Outputs of similar age
#107,606
of 267,324 outputs
Outputs of similar age from Clinical Epigenetics
#6
of 8 outputs
Altmetric has tracked 16,530,799 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 885 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,324 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.