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Mendeley readers
Attention Score in Context
| Title |
Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs
|
|---|---|
| Published in |
Malaria Journal, May 2010
|
| DOI | 10.1186/1475-2875-9-136 |
| Pubmed ID | |
| Authors |
Teun Bousema, Lucy Okell, Seif Shekalaghe, Jamie T Griffin, Sabah Omar, Patrick Sawa, Colin Sutherland, Robert Sauerwein, Azra C Ghani, Chris Drakeley |
| Abstract |
There is renewed acknowledgement that targeting gametocytes is essential for malaria control and elimination efforts. Simple mathematical models were fitted to data from clinical trials in order to determine the mean gametocyte circulation time and duration of gametocyte carriage in treated malaria patients. Data were used from clinical trials from East Africa. The first trial compared non-artemisinin combination therapy (non-ACT: sulphadoxine-pyrimethamine (SP) plus amodiaquine) and artemisinin-based combination therapy (ACT: SP plus artesunate (AS) or artemether-lumefantrine). The second trial compared ACT (SP+AS) with ACT in combination with a single dose of primaquine (ACT-PQ: SP+AS+PQ). Mature gametocytes were quantified in peripheral blood samples by nucleic acid sequence based amplification. A simple deterministic compartmental model was fitted to gametocyte densities to estimate the circulation time per gametocyte; a similar model was fitted to gametocyte prevalences to estimate the duration of gametocyte carriage after efficacious treatment. The mean circulation time of gametocytes was 4.6-6.5 days. After non-ACT treatment, patients were estimated to carry gametocytes for an average of 55 days (95% CI 28.7 - 107.7). ACT reduced the duration of gametocyte carriage fourfold to 13.4 days (95% CI 10.2-17.5). Addition of PQ to ACT resulted in a further fourfold reduction of the duration of gametocyte carriage. These findings confirm previous estimates of the circulation time of gametocytes, but indicate a much longer duration of (low density) gametocyte carriage after apparently successful clearance of asexual parasites. ACT shortened the period of gametocyte carriage considerably, and had the most pronounced effect on mature gametocytes when combined with PQ. |
Mendeley readers
The data shown below were compiled from readership statistics for 302 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| Tanzania, United Republic of | 1 | <1% |
| Italy | 1 | <1% |
| Ghana | 1 | <1% |
| Switzerland | 1 | <1% |
| South Africa | 1 | <1% |
| Brazil | 1 | <1% |
| Belgium | 1 | <1% |
| United States | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 291 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 71 | 24% |
| Researcher | 71 | 24% |
| Student > Master | 32 | 11% |
| Student > Bachelor | 21 | 7% |
| Student > Doctoral Student | 16 | 5% |
| Other | 45 | 15% |
| Unknown | 46 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 87 | 29% |
| Medicine and Dentistry | 53 | 18% |
| Biochemistry, Genetics and Molecular Biology | 30 | 10% |
| Immunology and Microbiology | 13 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 3% |
| Other | 46 | 15% |
| Unknown | 63 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2016.
All research outputs
#2,950,585
of 22,881,154 outputs
Outputs from Malaria Journal
#705
of 5,579 outputs
Outputs of similar age
#11,274
of 95,016 outputs
Outputs of similar age from Malaria Journal
#2
of 50 outputs
Altmetric has tracked 22,881,154 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,579 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,016 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.