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Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1

Overview of attention for article published in BMC Molecular and Cell Biology, October 2012
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Title
Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1
Published in
BMC Molecular and Cell Biology, October 2012
DOI 10.1186/1471-2091-13-20
Pubmed ID
Authors

Juha Grönholm, Sari Vanhatupa, Daniela Ungureanu, Jouni Väliaho, Tuomo Laitinen, Jarkko Valjakka, Olli Silvennoinen

Abstract

STAT1 is an essential transcription factor for interferon-γ-mediated gene responses. A distinct sumoylation consensus site (ψKxE) 702IKTE705 is localized in the C-terminal region of STAT1, where Lys703 is a target for PIAS-induced SUMO modification. Several studies indicate that sumoylation has an inhibitory role on STAT1-mediated gene expression but the molecular mechanisms are not fully understood.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 2%
Unknown 43 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 27%
Researcher 10 23%
Student > Master 4 9%
Other 3 7%
Student > Doctoral Student 3 7%
Other 6 14%
Unknown 6 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 45%
Immunology and Microbiology 8 18%
Biochemistry, Genetics and Molecular Biology 5 11%
Environmental Science 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 1 2%
Unknown 7 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2012.
All research outputs
#17,285,036
of 25,373,627 outputs
Outputs from BMC Molecular and Cell Biology
#778
of 1,233 outputs
Outputs of similar age
#126,339
of 192,233 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#9
of 25 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,233 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.