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Type IV collagen drives alveolar epithelial–endothelial association and the morphogenetic movements of septation

Overview of attention for article published in BMC Biology, July 2016
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Title
Type IV collagen drives alveolar epithelial–endothelial association and the morphogenetic movements of septation
Published in
BMC Biology, July 2016
DOI 10.1186/s12915-016-0281-2
Pubmed ID
Authors

Maria Loscertales, Fotini Nicolaou, Marion Jeanne, Mauro Longoni, Douglas B. Gould, Yunwei Sun, Faouzi I. Maalouf, Nandor Nagy, Patricia K. Donahoe

Abstract

Type IV collagen is the main component of the basement membrane that gives strength to the blood-gas barrier (BGB). In mammals, the formation of a mature BGB occurs primarily after birth during alveologenesis and requires the formation of septa from the walls of the saccule. In contrast, in avians, the formation of the BGB occurs rapidly and prior to hatching. Mutation in basement membrane components results in an abnormal alveolar phenotype; however, the specific role of type IV collagen in regulating alveologenesis remains unknown. We have performed a microarray expression analysis in late chick lung development and found that COL4A1 and COL4A2 were among the most significantly upregulated genes during the formation of the avian BGB. Using mouse models, we discovered that mutations in murine Col4a1 and Col4a2 genes affected the balance between lung epithelial progenitors and differentiated cells. Mutations in Col4a1 derived from the vascular component were sufficient to cause defects in vascular development and the BGB. We also show that Col4a1 and Col4a2 mutants displayed disrupted myofibroblast proliferation, differentiation and migration. Lastly, we revealed that addition of type IV collagen protein induced myofibroblast proliferation and migration in monolayer culture and increased the formation of mesenchymal-epithelial septal-like structures in co-culture. Our study showed that type IV collagen and, therefore the basement membrane, play fundamental roles in coordinating alveolar morphogenesis. In addition to its role in the formation of epithelium and vasculature, type IV collagen appears to be key for alveolar myofibroblast development by inducing their proliferation, differentiation and migration throughout the developing septum.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 66 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 19%
Researcher 10 15%
Student > Bachelor 8 12%
Student > Master 5 7%
Student > Postgraduate 4 6%
Other 8 12%
Unknown 19 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 15%
Medicine and Dentistry 10 15%
Agricultural and Biological Sciences 10 15%
Engineering 5 7%
Nursing and Health Professions 2 3%
Other 7 10%
Unknown 23 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2016.
All research outputs
#7,043,904
of 8,133,552 outputs
Outputs from BMC Biology
#851
of 874 outputs
Outputs of similar age
#217,823
of 257,634 outputs
Outputs of similar age from BMC Biology
#31
of 32 outputs
Altmetric has tracked 8,133,552 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 874 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.