Title |
Foxp3 overexpression in tumor cells predicts poor survival in oral squamous cell carcinoma
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Published in |
BMC Cancer, July 2016
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DOI | 10.1186/s12885-016-2419-6 |
Pubmed ID | |
Authors |
Jing-Jing Song, Si-Jia Zhao, Juan Fang, Da Ma, Xiang-Qi Liu, Xiao-Bing Chen, Yun Wang, Bin Cheng, Zhi Wang |
Abstract |
Forkhead Box P3 (Foxp3) is a regulatory T cells marker, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of Foxp3 expression with clinicopathological parameters and prognosis in oral squamous cell carcinoma (OSCC). Foxp3 expression was examined using immunohistochemistry (IHC) in paraffin-embedded tissue samples from 273 OSCC patients. Statistical analysis was performed to evaluate the associations between Foxp3 expression, the clinicopathologic characteristics and prognostic factors in OSCC. Foxp3 protein expression was significantly associated with lymph node metastasis (P <0.01). Both univariate and multivariate analyses revealed that Foxp3 was an independent factor for both 5 years overall survival (OS) and relapse-free survival (RFS) (both P <0.01). Patients with Foxp3 overexpression had shorter OS and RFS. Our results determined that elevated Foxp3 protein expression was a predictive factor of outcome in OSCC and could act as a promising therapeutic target. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Researcher | 2 | 11% |
Student > Master | 2 | 11% |
Student > Postgraduate | 2 | 11% |
Other | 2 | 11% |
Unknown | 7 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 26% |
Biochemistry, Genetics and Molecular Biology | 3 | 16% |
Immunology and Microbiology | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Unknown | 9 | 47% |