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Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012

Overview of attention for article published in BMC Microbiology, July 2016
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Title
Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012
Published in
BMC Microbiology, July 2016
DOI 10.1186/s12866-016-0786-4
Pubmed ID
Authors

Joanna Spinato, Élyse Boivin, Émilie Bélanger-Trudelle, Huguette Fauchon, Cécile Tremblay, Hafid Soualhine

Abstract

The increasing emergence of drug-resistant tuberculosis presents a threat to the effective control of tuberculosis (TB). Rapid detection of drug-resistance is more important than ever to address this scourge. The purpose of this study was to genotypically characterize the first-line antitubercular drug-resistant isolates collected over 11 years in Quebec. The main mutations found in our resistant strains collection (n = 225) include: the S315T substitution in katG (50.2 %), the -15 C/T mutation in the inhA promoter (29 %); the S531L substitution in rpoB (43 %); the deletion 8 bp 446 / + R140S in pncA (72.9 %); the M306I (35.7 %) and M306V (21.4 %) substitutions in embB. Ten of the mutations in katG and 4 mutations identified in pncA were previously undescribed. Screening of mutations conferring resistance to first-line antituberculous drugs using DNA-sequencing approach seems to be feasible and would drastically shorten the time to determine the resistance profile compared to the proportion method.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 20%
Student > Postgraduate 4 13%
Researcher 4 13%
Student > Master 3 10%
Other 3 10%
Other 5 17%
Unknown 5 17%
Readers by discipline Count As %
Medicine and Dentistry 7 23%
Immunology and Microbiology 6 20%
Biochemistry, Genetics and Molecular Biology 4 13%
Agricultural and Biological Sciences 2 7%
Nursing and Health Professions 1 3%
Other 2 7%
Unknown 8 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2016.
All research outputs
#15,557,505
of 23,881,329 outputs
Outputs from BMC Microbiology
#1,652
of 3,286 outputs
Outputs of similar age
#231,541
of 369,754 outputs
Outputs of similar age from BMC Microbiology
#57
of 99 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,286 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,754 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.