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Resistance training concomitant to radiotherapy of spinal bone metastases – survival and prognostic factors of a randomized trial

Overview of attention for article published in Radiation Oncology, July 2016
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  • Good Attention Score compared to outputs of the same age and source (70th percentile)

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Title
Resistance training concomitant to radiotherapy of spinal bone metastases – survival and prognostic factors of a randomized trial
Published in
Radiation Oncology, July 2016
DOI 10.1186/s13014-016-0675-x
Pubmed ID
Authors

Harald Rief, Thomas Bruckner, Ingmar Schlampp, Tilman Bostel, Thomas Welzel, Jürgen Debus, Robert Förster

Abstract

To compare the effects of resistance training versus passive physical therapy on bone survival in the metastatic bone during radiation therapy (RT) as combined treatment in patients with spinal bone metastases. Secondly, to evaluate overall survival and progression-free-survival (PFS) as well as to quantify prognostic factors of bone survival after combined treatment. In this randomized trial 60 patients were allocated from September 2011 until March 2013 into one of the two groups: resistance training (group A) or passive physical therapy (group B) with thirty patients in each group during RT. We estimated patient survival using Kaplan-Meier survival method. The Wald-test was used to evaluate the prognostic importance of pathological fracture, primary site, Karnofsky performance status, localization of metastases, number of metastases, and cerebral metastases. Median follow-up was 10 months (range 2-35). Bone survival showed no significant difference between groups (p = .303). Additionally no difference between groups could be detected in overall survival (p = .688) and PFS (p = .295). Local bone progression was detected in 16.7 % in group B, no irradiated bone in group A showed a local progression over the course (p = 0.019). In univariate analysis breast cancer, prostate cancer, and the presence of cerebral metastases had a significant impact on bone survival in group B, while no impact could be demonstrated in group A. In this group of patients with spinal bone metastases we were able to show that guided resistance training of the paravertebral muscles had no essential impact on survival concomitant to RT. Importantly, no local bone progression in group A was detected, nevertheless no prognostic factor for combined treatment could be evaluated. Clinical trial identifier NCT 01409720 . Registered 8 February 2011.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 172 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 <1%
Canada 1 <1%
Unknown 170 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 28 16%
Student > Master 19 11%
Student > Ph. D. Student 15 9%
Researcher 12 7%
Student > Postgraduate 10 6%
Other 27 16%
Unknown 61 35%
Readers by discipline Count As %
Medicine and Dentistry 37 22%
Nursing and Health Professions 34 20%
Sports and Recreations 19 11%
Biochemistry, Genetics and Molecular Biology 3 2%
Agricultural and Biological Sciences 3 2%
Other 14 8%
Unknown 62 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2016.
All research outputs
#15,380,359
of 22,881,154 outputs
Outputs from Radiation Oncology
#1,046
of 2,060 outputs
Outputs of similar age
#236,455
of 365,593 outputs
Outputs of similar age from Radiation Oncology
#9
of 37 outputs
Altmetric has tracked 22,881,154 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,060 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 365,593 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.