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Safety and immunogenecity of a live attenuated Rift Valley fever vaccine (CL13T) in camels

Overview of attention for article published in BMC Veterinary Research, July 2016
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Title
Safety and immunogenecity of a live attenuated Rift Valley fever vaccine (CL13T) in camels
Published in
BMC Veterinary Research, July 2016
DOI 10.1186/s12917-016-0775-8
Pubmed ID
Authors

S. Daouam, F. Ghzal, Y. Naouli, K. O. Tadlaoui, M. M. Ennaji, C. Oura, M. EL Harrak

Abstract

Rift Valley fever is an emerging zoonotic viral disease, enzootic and endemic in Africa and the Arabian Peninsula, which poses a significant threat to both human and animal health. The disease is most severe in ruminants causing abortions in pregnant animals, especially sheep animals and high mortality in young populations. High mortality rates and severe clinical manifestation have also been reported among camel populations in Africa, to attend however none of the currently available live vaccines against RVF have been tested for safety and efficacy in this species. In this study, the safety and efficacy (through a neutralizing antibody response) of the thermostable live attenuated RVF CL13T vaccine were evaluated in camels in two different preliminary experiments involving 16 camels, (that 12 camels and 4 pregnant camels). The study revealed that the CL13T vaccine was safe to use in camels and no abortions or teratogenic effects were observed. The single dose of the vaccine stimulated a strong and long-lasting neutralizing antibody response for up to 12 months. The presence of neutralization antibodies is likely to correlate with protection; however protection would need to be confirmed by challenge experiments using the virulent RVF virus.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 17%
Student > Master 4 11%
Professor > Associate Professor 3 9%
Student > Doctoral Student 2 6%
Other 2 6%
Other 6 17%
Unknown 12 34%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 20%
Immunology and Microbiology 4 11%
Medicine and Dentistry 4 11%
Veterinary Science and Veterinary Medicine 3 9%
Biochemistry, Genetics and Molecular Biology 3 9%
Other 3 9%
Unknown 11 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2016.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from BMC Veterinary Research
#1,558
of 3,297 outputs
Outputs of similar age
#251,212
of 380,089 outputs
Outputs of similar age from BMC Veterinary Research
#37
of 87 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,297 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 380,089 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.