Title |
Alternative mRNA fates identified in microRNA-associated transcriptome analysis
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Published in |
BMC Genomics, October 2012
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DOI | 10.1186/1471-2164-13-561 |
Pubmed ID | |
Authors |
Adam P Carroll, Nham Tran, Paul A Tooney, Murray J Cairns |
Abstract |
MicroRNA (miRNA) are small non-coding RNA molecules which function as nucleic acid-based specificity factors in the universal RNA binding complex known as the RNA induced silencing complex (RISC). In the canonical gene-silencing pathway, these activated RISC particles are associated with RNA decay and gene suppression, however, there is evidence to suggest that in some circumstances they may also stabilise their target RNA and even enhance translation. To further explore the role of miRNA in this context, we performed a genome-wide expression analysis to investigate the molecular consequences of bidirectional modulation of the disease-associated miRNAs miR-181b and miR-107 in multiple human cell lines. |
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Australia | 1 | 14% |
Spain | 1 | 14% |
Montenegro | 1 | 14% |
France | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
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Scientists | 4 | 57% |
Members of the public | 3 | 43% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | 2% |
United States | 1 | 2% |
India | 1 | 2% |
Australia | 1 | 2% |
Unknown | 41 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 31% |
Student > Master | 8 | 18% |
Professor > Associate Professor | 7 | 16% |
Student > Ph. D. Student | 5 | 11% |
Professor | 4 | 9% |
Other | 6 | 13% |
Unknown | 1 | 2% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 9 | 20% |
Medicine and Dentistry | 3 | 7% |
Neuroscience | 2 | 4% |
Economics, Econometrics and Finance | 1 | 2% |
Other | 1 | 2% |
Unknown | 3 | 7% |