Title |
First-episode psychosis in a 15 year-old female with clinical presentation of anti-NMDA receptor encephalitis: a case report and review of the literature
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Published in |
BMC Research Notes, July 2016
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DOI | 10.1186/s13104-016-2180-6 |
Pubmed ID | |
Authors |
Maria Moura, Amilcar Silva-dos-Santos, Joana Afonso, Miguel Talina |
Abstract |
Anti-NMDA receptor encephalitis is an autoimmune disease that was identified in 2007, and manifests in a stepwise manner with psychiatric, neurological and autonomic symptoms. The disease is caused by autoantibodies against NMDA receptors. It can have a paraneoplastic origin, mainly secondary to ovarian teratomas, but it can also be unrelated to the tumor. This disease can affect both sexes and all ages. Here, we present a case of a 15 year-old female adolescent with first-episode psychosis with anti-NMDA receptor encephalitis not related to tumor, which manifested with delusion, hallucinations, panic attacks, agitation, and neurological symptoms, and later with autonomic instability. She was treated with immunotherapy and psychiatric medication resulting in improvement of her main psychiatric and neurological symptoms. Our main objective in presenting this case is to alert clinicians to this challenging and recent disease that has a clinical presentation that might resemble a functional psychiatric condition and can be underdiagnosed in the context of child and adolescent psychiatry. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | 25% |
United Kingdom | 1 | 25% |
United States | 1 | 25% |
Portugal | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Bangladesh | 1 | 2% |
Unknown | 63 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 14% |
Researcher | 9 | 14% |
Student > Master | 7 | 11% |
Student > Doctoral Student | 7 | 11% |
Student > Bachelor | 7 | 11% |
Other | 13 | 20% |
Unknown | 12 | 19% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 21 | 33% |
Psychology | 10 | 16% |
Neuroscience | 8 | 13% |
Nursing and Health Professions | 4 | 6% |
Agricultural and Biological Sciences | 3 | 5% |
Other | 4 | 6% |
Unknown | 14 | 22% |