You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats
|
|---|---|
| Published in |
BMC Gastroenterology, July 2016
|
| DOI | 10.1186/s12876-016-0500-x |
| Pubmed ID | |
| Authors |
Mingming Zhang, Qian Zhou, Robert G. Dorfman, Xiaoli Huang, Tingting Fan, Hao Zhang, Jun Zhang, Chenggong Yu |
| Abstract |
Butyrate is an energy source for colonocytes that is formed by bacterial fermentation of dietary fiber in the colon and that exerts broad anti-inflammatory activities. Although the administration of butyrate improves homeostasis in patients and ameliorates IBD (Inflammatory Bowel Disease)-related lesions and symptoms, the anti-inflammatory mechanisms of butyrate still remain unclear. To explore the impact of butyrate on Treg (Regulatory T cell)/Th17 (T helper 17 cell) differentiation and colitis in rats. The effect of butyrate on the expression of markers related to both Tregs and Th17 cells were determined in human monocytes as well as a rat model of colitis induced by 2,4,6-trinitrobenzene sulfonic acid. Rats were treated with butyrate in vivo, whereas the rat splenocytes and human monocytes were treated in vitro. We found that butyrate administration increased peripheral blood Treg cell levels as well as plasma levels of anti-Th17 cytokines (IL-10 and IL-12). Butyrate administration further suppressed IL-17 levels in both plasma and colonic mucosa, and ameliorated colonic colitis lesions in rats. This promotion of Treg activity and inhibition of IL-17 release was also observed in human venous monocytes and rat splenocytes in vitro. Our results suggest that butyrate plays a key role in regulating the Treg/Th17 balance and ultimately protects the colon mucosa against the development of IBD. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 25% |
| Ireland | 1 | 13% |
| United States | 1 | 13% |
| Australia | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 63% |
| Scientists | 2 | 25% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 153 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 15% |
| Student > Bachelor | 22 | 14% |
| Student > Master | 17 | 11% |
| Student > Doctoral Student | 15 | 10% |
| Researcher | 15 | 10% |
| Other | 17 | 11% |
| Unknown | 44 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 14% |
| Biochemistry, Genetics and Molecular Biology | 20 | 13% |
| Agricultural and Biological Sciences | 20 | 13% |
| Immunology and Microbiology | 19 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
| Other | 9 | 6% |
| Unknown | 55 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2023.
All research outputs
#7,244,861
of 25,654,806 outputs
Outputs from BMC Gastroenterology
#482
of 2,024 outputs
Outputs of similar age
#115,093
of 381,510 outputs
Outputs of similar age from BMC Gastroenterology
#8
of 26 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 2,024 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 381,510 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.