Title |
Increased Nociceptive Sensitivity and Nociceptin/Orphanin FQ Levels in a Rat Model of PTSD
|
---|---|
Published in |
Molecular Pain, January 2012
|
DOI | 10.1186/1744-8069-8-76 |
Pubmed ID | |
Authors |
Yong Zhang, Priyam R Gandhi, Kelly M Standifer |
Abstract |
Clinical studies indicate that post-traumatic stress disorder (PTSD) frequently shares co-morbidity with chronic pain. Although in animals acute stress-induced antinociception is well documented, the effect of PTSD-like stress on nociceptive sensitivity is unclear. Though a few studies measured nociceptive responses at a single time point, no studies have examined changes in nociceptive sensitivity over time following exposure to PTSD-like stress. Nociceptin/orphanin FQ (N/OFQ), an endogenous ligand for the N/OFQ peptide (NOP) receptor, modulates various biological functions in the central nervous system that are affected by PTSD, including nociceptive sensitivity, stress and anxiety, learning and memory. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 59 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 24% |
Student > Bachelor | 7 | 12% |
Researcher | 6 | 10% |
Professor > Associate Professor | 5 | 8% |
Other | 4 | 7% |
Other | 10 | 17% |
Unknown | 13 | 22% |
Readers by discipline | Count | As % |
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Neuroscience | 13 | 22% |
Agricultural and Biological Sciences | 10 | 17% |
Psychology | 5 | 8% |
Medicine and Dentistry | 5 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 4 | 7% |
Unknown | 19 | 32% |