Title |
MicroRNA-125b-5p suppresses Brucella abortus intracellular survival via control of A20 expression
|
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Published in |
BMC Microbiology, July 2016
|
DOI | 10.1186/s12866-016-0788-2 |
Pubmed ID | |
Authors |
Ning Liu, Lin Wang, Changjiang Sun, Li Yang, Wanchun Sun, Qisheng Peng |
Abstract |
Brucella may establish chronic infection by regulating the expression of miRNAs. However, the role of miRNAs in modulating the intracellular growth of Brucella remains unclear. In this study, we show that Brucella. abortus infection leads to downregulation of miR-125b-5p in macrophages. We establish that miR-125b-5p targets A20, an inhibitor of the NF-kB activation. Additionally, expression of miR-125b-5p decreases A20 expression in B. abortus-infected macrophages and leads to NF-kB activation and increased production of TNFα. Furthermore, B. abortus survival is attenuated in the presence of miR-125b-5p. These results uncover a role for miR-125b-5p in the regulation of B. abortus intracellular survival via the control of A20 expression. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Venezuela, Bolivarian Republic of | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 19% |
Researcher | 3 | 14% |
Student > Postgraduate | 3 | 14% |
Student > Ph. D. Student | 2 | 10% |
Professor > Associate Professor | 2 | 10% |
Other | 2 | 10% |
Unknown | 5 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 29% |
Immunology and Microbiology | 5 | 24% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Other | 3 | 14% |
Unknown | 4 | 19% |