Title |
Macrophages and angiogenesis: a role for Wnt signaling
|
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Published in |
Vascular Cell, August 2012
|
DOI | 10.1186/2045-824x-4-13 |
Pubmed ID | |
Authors |
Andrew C Newman, Christopher C W Hughes |
Abstract |
Macrophages regulate many developmental and pathological processes in both embryonic and adult tissues, and recent studies have shown a significant role in angiogenesis. Similarly, Wnt signaling is fundamental to tissue morphogenesis and also has a role in vascular development. In this review, we summarize recent advances in the field of macrophage-regulated angiogenesis, with a focus on the role of macrophage-derived Wnt ligands. We review data that provide both direct and indirect evidence for macrophage-derived Wnt regulation of physiologic and pathologic angiogenesis. Finally, we propose that Wnt signaling plays a central role in differentiation of tumor associated and wound infiltrating macrophages to a proangiogenic phenotype. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Germany | 1 | <1% |
Unknown | 126 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 44 | 34% |
Researcher | 21 | 16% |
Student > Master | 11 | 9% |
Student > Doctoral Student | 8 | 6% |
Student > Bachelor | 8 | 6% |
Other | 21 | 16% |
Unknown | 15 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 45 | 35% |
Biochemistry, Genetics and Molecular Biology | 22 | 17% |
Medicine and Dentistry | 20 | 16% |
Engineering | 5 | 4% |
Immunology and Microbiology | 4 | 3% |
Other | 10 | 8% |
Unknown | 22 | 17% |