Title |
Correlation analyses of clinical and molecular findings identify candidate biological pathways in systemic juvenile idiopathic arthritis
|
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Published in |
BMC Medicine, October 2012
|
DOI | 10.1186/1741-7015-10-125 |
Pubmed ID | |
Authors |
Xuefeng B Ling, Claudia Macaubas, Heather C Alexander, Qiaojun Wen, Edward Chen, Sihua Peng, Yue Sun, Chetan Deshpande, Kuang-Hung Pan, Richard Lin, Chih-Jian Lih, Sheng-Yung P Chang, Tzielan Lee, Christy Sandborg, Ann B Begovich, Stanley N Cohen, Elizabeth D Mellins |
Abstract |
Clinicians have long appreciated the distinct phenotype of systemic juvenile idiopathic arthritis (SJIA) compared to polyarticular juvenile idiopathic arthritis (POLY). We hypothesized that gene expression profiles of peripheral blood mononuclear cells (PBMC) from children with each disease would reveal distinct biological pathways when analyzed for significant associations with elevations in two markers of JIA activity, erythrocyte sedimentation rate (ESR) and number of affected joints (joint count, JC). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 3% |
Unknown | 37 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 21% |
Student > Bachelor | 8 | 21% |
Other | 7 | 18% |
Student > Master | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Other | 6 | 16% |
Unknown | 3 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 58% |
Biochemistry, Genetics and Molecular Biology | 6 | 16% |
Agricultural and Biological Sciences | 4 | 11% |
Unspecified | 1 | 3% |
Unknown | 5 | 13% |