Title |
Rescue from acute neuroinflammation by pharmacological chemokine-mediated deviation of leukocytes
|
---|---|
Published in |
Journal of Neuroinflammation, October 2012
|
DOI | 10.1186/1742-2094-9-243 |
Pubmed ID | |
Authors |
Nele Berghmans, Hubertine Heremans, Sandra Li, Erik Martens, Patrick Matthys, Lydia Sorokin, Jo Van Damme, Ghislain Opdenakker |
Abstract |
Neutrophil influx is an important sign of hyperacute neuroinflammation, whereas the entry of activated lymphocytes into the brain parenchyma is a hallmark of chronic inflammatory processes, as observed in multiple sclerosis (MS) and its animal models of experimental autoimmune encephalomyelitis (EAE). Clinically approved or experimental therapies for neuroinflammation act by blocking leukocyte penetration of the blood brain barrier. However, in view of unsatisfactory results and severe side effects, complementary therapies are needed. We have examined the effect of chlorite-oxidized oxyamylose (COAM), a potent antiviral polycarboxylic acid on EAE. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 19% |
Student > Doctoral Student | 5 | 14% |
Student > Bachelor | 5 | 14% |
Researcher | 5 | 14% |
Student > Ph. D. Student | 5 | 14% |
Other | 5 | 14% |
Unknown | 4 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 25% |
Agricultural and Biological Sciences | 8 | 22% |
Neuroscience | 5 | 14% |
Immunology and Microbiology | 4 | 11% |
Medicine and Dentistry | 2 | 6% |
Other | 4 | 11% |
Unknown | 4 | 11% |