Title |
Quantitative GPCR and ion channel transcriptomics in primary alveolar macrophages and macrophage surrogates
|
---|---|
Published in |
BMC Immunology, October 2012
|
DOI | 10.1186/1471-2172-13-57 |
Pubmed ID | |
Authors |
Paul J Groot-Kormelink, Lindsay Fawcett, Paul D Wright, Martin Gosling, Toby C Kent |
Abstract |
Alveolar macrophages are one of the first lines of defence against invading pathogens and play a central role in modulating both the innate and acquired immune systems. By responding to endogenous stimuli within the lung, alveolar macrophages contribute towards the regulation of the local inflammatory microenvironment, the initiation of wound healing and the pathogenesis of viral and bacterial infections. Despite the availability of protocols for isolating primary alveolar macrophages from the lung these cells remain recalcitrant to expansion in-vitro and therefore surrogate cell types, such as monocyte derived macrophages and phorbol ester-differentiated cell lines (e.g. U937, THP-1, HL60) are frequently used to model macrophage function. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Argentina | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Korea, Republic of | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 12 | 29% |
Student > Master | 9 | 22% |
Student > Ph. D. Student | 9 | 22% |
Professor | 2 | 5% |
Student > Bachelor | 2 | 5% |
Other | 3 | 7% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 27% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 17% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Chemistry | 3 | 7% |
Immunology and Microbiology | 3 | 7% |
Other | 8 | 20% |
Unknown | 5 | 12% |