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Application of a simplified definition of diastolic function in severe sepsis and septic shock

Overview of attention for article published in Critical Care, August 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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66 X users

Citations

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82 Dimensions

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102 Mendeley
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Title
Application of a simplified definition of diastolic function in severe sepsis and septic shock
Published in
Critical Care, August 2016
DOI 10.1186/s13054-016-1421-3
Pubmed ID
Authors

Michael J. Lanspa, Andrea R. Gutsche, Emily L. Wilson, Troy D. Olsen, Eliotte L. Hirshberg, Daniel B. Knox, Samuel M. Brown, Colin K. Grissom

Abstract

Left ventricular diastolic dysfunction is common in patients with severe sepsis or septic shock, but the best approach to categorization is unknown. We assessed the association of common measures of diastolic function with clinical outcomes and tested the utility of a simplified definition of diastolic dysfunction against the American Society of Echocardiography (ASE) 2009 definition. In this prospective observational study, patients with severe sepsis or septic shock underwent transthoracic echocardiography within 24 h of onset of sepsis (median 4.3 h). We measured echocardiographic parameters of diastolic function and used random forest analysis to assess their association with clinical outcomes (28-day mortality and ICU-free days to day 28) and thereby suggest a simplified definition. We then compared patients categorized by the ASE 2009 definition and our simplified definition. We studied 167 patients. The ASE 2009 definition categorized only 35 % of patients. Random forest analysis demonstrated that the left atrial volume index and deceleration time, central to the ASE 2009 definition, were not associated with clinical outcomes. Our simplified definition used only e' and E/e', omitting the other measurements. The simplified definition categorized 87 % of patients. Patients categorized by either ASE 2009 or our novel definition had similar clinical outcomes. In both definitions, worsened diastolic function was associated with increased prevalence of ischemic heart disease, diabetes, and hypertension. A novel, simplified definition of diastolic dysfunction categorized more patients with sepsis than ASE 2009 definition. Patients categorized according to the simplified definition did not differ from patients categorized according to the ASE 2009 definition in respect to clinical outcome or comorbidities.

X Demographics

X Demographics

The data shown below were collected from the profiles of 66 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
South Africa 1 <1%
Unknown 100 98%

Demographic breakdown

Readers by professional status Count As %
Other 15 15%
Student > Master 12 12%
Student > Postgraduate 11 11%
Researcher 8 8%
Student > Ph. D. Student 8 8%
Other 28 27%
Unknown 20 20%
Readers by discipline Count As %
Medicine and Dentistry 57 56%
Nursing and Health Professions 7 7%
Social Sciences 5 5%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Business, Management and Accounting 1 <1%
Other 8 8%
Unknown 22 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2021.
All research outputs
#1,120,310
of 25,793,330 outputs
Outputs from Critical Care
#888
of 6,623 outputs
Outputs of similar age
#21,265
of 383,555 outputs
Outputs of similar age from Critical Care
#40
of 108 outputs
Altmetric has tracked 25,793,330 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,623 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.6. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 383,555 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.