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Evolutionary and functional analysis of mulberry type III polyketide synthases

Overview of attention for article published in BMC Genomics, August 2016
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Title
Evolutionary and functional analysis of mulberry type III polyketide synthases
Published in
BMC Genomics, August 2016
DOI 10.1186/s12864-016-2843-7
Pubmed ID
Authors

Han Li, Jiubo Liang, Hu Chen, Guangyu Ding, Bi Ma, Ningjia He

Abstract

Type III polyketide synthases are important for the biosynthesis of flavonoids and various plant polyphenols. Mulberry plants have abundant polyphenols, but very little is known about the mulberry type III polyketide synthase genes. An analysis of these genes may provide new targets for genetic improvement to increase relevant secondary metabolites and enhance the plant tolerance to biotic and abiotic stresses. Eighteen genes encoding type III polyketide synthases were identified, including six chalcone synthases (CHS), ten stilbene synthases (STS), and two polyketide synthases (PKS). Functional characterization of four genes representing most of the MnCHS and MnSTS genes by coexpression with 4-Coumaroyl-CoA ligase in Escherichia coli indicated that their products were able to catalyze p-coumaroyl-CoA and malonyl-CoA to generate naringenin and resveratrol, respectively. Microsynteny analysis within mulberry indicated that segmental and tandem duplication events contributed to the expansion of the MnCHS family, while tandem duplications were mainly responsible for the generation of the MnSTS genes. Combining the evolution and expression analysis results of the mulberry type III PKS genes indicated that MnCHS and MnSTS genes evolved mainly under purifying selection to maintain their original functions, but transcriptional subfunctionalization occurred during long-term species evolution. Moreover, mulberry leaves can rapidly accumulated oxyresveratrol after UV-C irradiation, suggesting that resveratrol was converted to oxyresveratrol. Characterizing the functions and evolution of mulberry type III PKS genes is crucial for advancing our understanding of these genes and providing the basis for further studies on the biosynthesis of relevant secondary metabolites in mulberry plants.

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Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 46%
Researcher 7 25%
Student > Master 2 7%
Professor 1 4%
Student > Doctoral Student 1 4%
Other 2 7%
Unknown 2 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 46%
Agricultural and Biological Sciences 10 36%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Chemistry 1 4%
Unknown 2 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2016.
All research outputs
#7,068,007
of 8,166,192 outputs
Outputs from BMC Genomics
#5,120
of 5,773 outputs
Outputs of similar age
#217,584
of 257,711 outputs
Outputs of similar age from BMC Genomics
#242
of 269 outputs
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