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miRNA-135a promotes hepatocellular carcinoma cell migration and invasion by targeting forkhead box O1

Overview of attention for article published in Cancer Cell International, August 2016
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1 tweeter

Citations

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Title
miRNA-135a promotes hepatocellular carcinoma cell migration and invasion by targeting forkhead box O1
Published in
Cancer Cell International, August 2016
DOI 10.1186/s12935-016-0328-z
Pubmed ID
Authors

Yue-Bin Zeng, Xing-Hua Liang, Guang-Xian Zhang, Nan Jiang, Tong Zhang, Jian-Ying Huang, Lei Zhang, Xian-Cheng Zeng

Abstract

Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. Many microRNAs (miRNAs), small non-coding RNAs, are involved in regulating cancer cell proliferation, metastasis, migration, invasion and apoptosis. We investigated the expression of miR-135a in HCC cell lines and clinical tissues. The effect of miR-135a on migration and invasion of HepG2 and MHCC-97L were examined using wound healing and Transwell assay. We determined the expression of miR-135a, forkhead box O1 (FOXO1), matrix metalloproteinase-2 (MMP-2) and Snail using real-time PCR and western blotting. We found miR-135a was upregulated in HCC cell lines and tissues. miR-135a overexpression promoted HCC cells migration and invasion, whereas miR-135a inhibition suppressed HCC cells migration and invasion. miR-135a overexpression could upregulate the expression of MMP2, Snail and the phosphorylation of AKT, but decreased FOXO3a phosporylation. Tumor suppressor FOXO1 was the direct target for miR-135a. Our results suggested that miR-135a might play an important role in promoting migration and invasion in HCC and presents a novel mechanism of miRNA-mediated direct suppression of FOXO1 in HCC cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 20%
Other 2 13%
Student > Doctoral Student 2 13%
Student > Ph. D. Student 1 7%
Lecturer 1 7%
Other 2 13%
Unknown 4 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 33%
Medicine and Dentistry 4 27%
Immunology and Microbiology 1 7%
Unknown 5 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2016.
All research outputs
#7,068,009
of 8,166,192 outputs
Outputs from Cancer Cell International
#248
of 318 outputs
Outputs of similar age
#217,583
of 257,712 outputs
Outputs of similar age from Cancer Cell International
#6
of 6 outputs
Altmetric has tracked 8,166,192 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 318 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,712 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.