You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
A reduction in CD90 (THY-1) expression results in increased differentiation of mesenchymal stromal cells
|
|---|---|
| Published in |
Stem Cell Research & Therapy, July 2016
|
| DOI | 10.1186/s13287-016-0359-3 |
| Pubmed ID | |
| Authors |
Daniela A. Moraes, Tatiana T. Sibov, Lorena F. Pavon, Paula Q. Alvim, Raphael S. Bonadio, Jaqueline R. Da Silva, Aline Pic-Taylor, Orlando A. Toledo, Luciana C. Marti, Ricardo B. Azevedo, Daniela M. Oliveira |
| Abstract |
Mesenchymal stromal cells (MSCs) are multipotent progenitor cells used in several cell therapies. MSCs are characterized by the expression of CD73, CD90, and CD105 cell markers, and the absence of CD34, CD45, CD11a, CD19, and HLA-DR cell markers. CD90 is a glycoprotein present in the MSC membranes and also in adult cells and cancer stem cells. The role of CD90 in MSCs remains unknown. Here, we sought to analyse the role that CD90 plays in the characteristic properties of in vitro expanded human MSCs. We investigated the function of CD90 with regard to morphology, proliferation rate, suppression of T-cell proliferation, and osteogenic/adipogenic differentiation of MSCs by reducing the expression of this marker using CD90-target small hairpin RNA lentiviral vectors. The present study shows that a reduction in CD90 expression enhances the osteogenic and adipogenic differentiation of MSCs in vitro and, unexpectedly, causes a decrease in CD44 and CD166 expression. Our study suggests that CD90 controls the differentiation of MSCs by acting as an obstacle in the pathway of differentiation commitment. This may be overcome in the presence of the correct differentiation stimuli, supporting the idea that CD90 level manipulation may lead to more efficient differentiation rates in vitro. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 248 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 247 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 20% |
| Student > Master | 45 | 18% |
| Student > Bachelor | 30 | 12% |
| Researcher | 27 | 11% |
| Student > Doctoral Student | 13 | 5% |
| Other | 32 | 13% |
| Unknown | 52 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 56 | 23% |
| Medicine and Dentistry | 39 | 16% |
| Agricultural and Biological Sciences | 28 | 11% |
| Immunology and Microbiology | 13 | 5% |
| Veterinary Science and Veterinary Medicine | 8 | 3% |
| Other | 39 | 16% |
| Unknown | 65 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2022.
All research outputs
#4,320,093
of 23,426,104 outputs
Outputs from Stem Cell Research & Therapy
#425
of 2,465 outputs
Outputs of similar age
#77,401
of 367,951 outputs
Outputs of similar age from Stem Cell Research & Therapy
#14
of 41 outputs
Altmetric has tracked 23,426,104 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,465 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,951 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.