Title |
Receptor specificity and erythrocyte binding preferences of avian influenza viruses isolated from India
|
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Published in |
Virology Journal, October 2012
|
DOI | 10.1186/1743-422x-9-251 |
Pubmed ID | |
Authors |
Shailesh D Pawar, Saurabh S Parkhi, Santosh S Koratkar, Akhilesh C Mishra |
Abstract |
Hemagglutination (HA) and hemagglutination inhibition (HI) assays are conventionally used for detection and identification of influenza viruses. HI assay is also used for detection of antibodies against influenza viruses. Primarily turkey or chicken erythrocytes [red blood cells (RBCs)] are used in these assays, as they are large, nucleated, and sediment fast, which makes it easy to determine the titer. Human influenza viruses agglutinate RBCs from chicken, human, and guinea pig, but not from horse. Human influenza viruses bind preferentially to sialic acid (SA) linked to galactose (Gal) by α 2, 6 linkage (SA α 2, 6-Gal), whereas avian influenza (AI) viruses bind preferentially to SA α 2, 3-Gal linkages. With this background, the present study was undertaken to study erythrocyte binding preferences and receptor specificities of AI viruses isolated from India. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 25% |
Researcher | 11 | 25% |
Student > Bachelor | 5 | 11% |
Student > Master | 5 | 11% |
Other | 3 | 7% |
Other | 5 | 11% |
Unknown | 4 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 48% |
Immunology and Microbiology | 4 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Chemistry | 3 | 7% |
Medicine and Dentistry | 3 | 7% |
Other | 5 | 11% |
Unknown | 5 | 11% |