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Identification of myeloid derived suppressor cells in the peripheral blood of tumor bearing dogs

Overview of attention for article published in BMC Veterinary Research, October 2012
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  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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Citations

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Title
Identification of myeloid derived suppressor cells in the peripheral blood of tumor bearing dogs
Published in
BMC Veterinary Research, October 2012
DOI 10.1186/1746-6148-8-209
Pubmed ID
Authors

Matthew Sherger, William Kisseberth, Cheryl London, Susan Olivo-Marston, Tracey L Papenfuss

Abstract

Myeloid derived suppressor cells (MDSCs) are a recently described population of immune cells that significantly contribute to the immunosuppression seen in cancer patients. MDSCs are one of the most important factors that limit the efficacy of cancer immunotherapy (e.g. cancer vaccines) and MDSC levels are increased in cancer in multiple species. Identifying and targeting MDSCs is actively being investigated in the field of human oncology and is increasingly being investigated in veterinary oncology. The treatment of canine cancer not only benefits dogs, but is being used for translational studies evaluating and modifying candidate therapies for use in humans. Thus, it is necessary to understand the immune alterations seen in canine cancer patients which, to date, have been relatively limited. This study investigates the use of commercially available canine antibodies to detect an immunosuppressive (CD11b low/CADO48 low) cell population that is increased in the peripheral blood of tumor-bearing dogs.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Poland 1 2%
Unknown 57 97%

Demographic breakdown

Readers by professional status Count As %
Other 9 15%
Student > Ph. D. Student 9 15%
Student > Postgraduate 9 15%
Student > Master 9 15%
Professor > Associate Professor 6 10%
Other 13 22%
Unknown 4 7%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 20 34%
Medicine and Dentistry 15 25%
Agricultural and Biological Sciences 7 12%
Immunology and Microbiology 6 10%
Biochemistry, Genetics and Molecular Biology 3 5%
Other 2 3%
Unknown 6 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2012.
All research outputs
#14,737,203
of 22,684,168 outputs
Outputs from BMC Veterinary Research
#1,238
of 3,034 outputs
Outputs of similar age
#112,363
of 184,188 outputs
Outputs of similar age from BMC Veterinary Research
#15
of 43 outputs
Altmetric has tracked 22,684,168 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,034 research outputs from this source. They receive a mean Attention Score of 3.8. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 184,188 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.