Title |
Identification of myeloid derived suppressor cells in the peripheral blood of tumor bearing dogs
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Published in |
BMC Veterinary Research, October 2012
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DOI | 10.1186/1746-6148-8-209 |
Pubmed ID | |
Authors |
Matthew Sherger, William Kisseberth, Cheryl London, Susan Olivo-Marston, Tracey L Papenfuss |
Abstract |
Myeloid derived suppressor cells (MDSCs) are a recently described population of immune cells that significantly contribute to the immunosuppression seen in cancer patients. MDSCs are one of the most important factors that limit the efficacy of cancer immunotherapy (e.g. cancer vaccines) and MDSC levels are increased in cancer in multiple species. Identifying and targeting MDSCs is actively being investigated in the field of human oncology and is increasingly being investigated in veterinary oncology. The treatment of canine cancer not only benefits dogs, but is being used for translational studies evaluating and modifying candidate therapies for use in humans. Thus, it is necessary to understand the immune alterations seen in canine cancer patients which, to date, have been relatively limited. This study investigates the use of commercially available canine antibodies to detect an immunosuppressive (CD11b low/CADO48 low) cell population that is increased in the peripheral blood of tumor-bearing dogs. |
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Mendeley readers
Geographical breakdown
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United States | 1 | 2% |
Poland | 1 | 2% |
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Other | 9 | 15% |
Student > Ph. D. Student | 9 | 15% |
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Professor > Associate Professor | 6 | 10% |
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Biochemistry, Genetics and Molecular Biology | 3 | 5% |
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