Title |
Common threads in cardiac fibrosis, infarct scar formation, and wound healing
|
---|---|
Published in |
Fibrogenesis & Tissue Repair, November 2012
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DOI | 10.1186/1755-1536-5-19 |
Pubmed ID | |
Authors |
Michael P Czubryt |
Abstract |
Wound healing, cardiac fibrosis, and infarct scar development, while possessing distinct features, share a number of key functional similarities, including extracellular matrix synthesis and remodeling by fibroblasts and myofibroblasts. Understanding the underlying mechanisms that are common to these processes may suggest novel therapeutic approaches for pathologic situations such as fibrosis, or defective wound healing such as hypertrophic scarring or keloid formation. This manuscript will briefly review the major steps of wound healing, and will contrast this process with how cardiac infarct scar formation or interstitial fibrosis occurs. The feasibility of targeting common pro-fibrotic growth factor signaling pathways will be discussed. Finally, the potential exploitation of novel regulators of wound healing and fibrosis (ski and scleraxis), will be examined. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 179 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 50 | 28% |
Student > Bachelor | 33 | 18% |
Student > Master | 21 | 12% |
Researcher | 19 | 10% |
Student > Postgraduate | 11 | 6% |
Other | 23 | 13% |
Unknown | 24 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 35 | 19% |
Agricultural and Biological Sciences | 32 | 18% |
Medicine and Dentistry | 32 | 18% |
Engineering | 23 | 13% |
Nursing and Health Professions | 5 | 3% |
Other | 24 | 13% |
Unknown | 30 | 17% |