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Characterization of virulent Newcastle disease viruses from vaccinated chicken flocks in Eastern China

Overview of attention for article published in BMC Veterinary Research, June 2016
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Title
Characterization of virulent Newcastle disease viruses from vaccinated chicken flocks in Eastern China
Published in
BMC Veterinary Research, June 2016
DOI 10.1186/s12917-016-0732-6
Pubmed ID
Authors

Jie Zhu, Shunlin Hu, Haixu Xu, Jingjing Liu, Zhenzhen Zhao, Xiaoquan Wang, Xiufan Liu

Abstract

Newcastle disease (ND) is one of the most contagious and devastating diseases to poultry in the world. The causative agents are virulent strains of Newcastle disease virus (NDV), which belong to the genus Avulavirus, sub-family Paramyxoviridae, family Paramyxovirinae. Knowing the genomic and antigenic characteristics of virulent NDVs might contribute to ND control in China. The results showed that all of the virulent strains belonged sub-genotype VIId shared the same cleavage site (112)RRQKR/F(117) in the fusion protein. At least 69 % (38 of 55) of the NDV strains possessed E347K variation in the hemagglutinin-neuraminidase protein. The cross-neutralization tests confirmed that the strains harboring 347 K showed lower antigenic relatedness with LaSota. Furthermore, the immune-challenge experiment indicated that LaSota could not provide complete protection against infection with the E347K variant NDVs as the vaccinated birds were still able to be infected and shed virulent challenge viruses. Currently, sub-genotype VIId NDVs are the prevalent virulent strains circulating among vaccinated chicken flocks in Eastern China. Our findings indicated that the E347K variation in HN gene would expand the antigenic difference with LaSota, which may be responsible for the increasing isolation rate of these strains from vaccinated chickens.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 23%
Student > Ph. D. Student 6 20%
Student > Master 5 17%
Other 3 10%
Professor 1 3%
Other 3 10%
Unknown 5 17%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 12 40%
Biochemistry, Genetics and Molecular Biology 2 7%
Agricultural and Biological Sciences 2 7%
Medicine and Dentistry 2 7%
Unspecified 1 3%
Other 4 13%
Unknown 7 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2016.
All research outputs
#6,220,251
of 8,192,854 outputs
Outputs from BMC Veterinary Research
#785
of 1,236 outputs
Outputs of similar age
#182,705
of 257,285 outputs
Outputs of similar age from BMC Veterinary Research
#53
of 82 outputs
Altmetric has tracked 8,192,854 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,236 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.