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Mendeley readers
| Title |
Disposable screen printed sensor for the electrochemical detection of delta-9-tetrahydrocannabinol in undiluted saliva
|
|---|---|
| Published in |
BMC Chemistry, January 2016
|
| DOI | 10.1186/s13065-016-0148-1 |
| Pubmed ID | |
| Authors |
Ceri Wanklyn, Dan Burton, Emma Enston, Carrie-Ann Bartlett, Sarah Taylor, Aleksandra Raniczkowska, Murdo Black, Lindy Murphy |
| Abstract |
Cannabis has an adverse effect on the ability to drive safely, therefore a rapid disposable test for Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the psychoactive component of cannabis, is highly desirable for roadside testing. A screen printed carbon electrode is used for the N-(4-amino-3-methoxyphenyl)-methanesulfonamide mediated detection of Δ(9)-THC in saliva. Mediator placed in an overlayer was galvanostatically oxidized and reacted with Δ(9)-THC to give an electrochemically active adduct which could be detected by chronoamperometric reduction. Detection of 25-50 ng/mL Δ(9)-THC spiked into undiluted saliva was achieved with a response time of 30 s. A trial of the sensors with four cannabis smokers showed sensitivity of 28 %, specificity of 99 % and accuracy of 52 %. Rapid electrochemical detection of Δ(9)-THC in undiluted saliva has been demonstrated using a disposable sensor, however the sensitivity is lower than acceptable. Further optimization of the assay and sensor format is required to improve the sensitivity of response to Δ(9)-THC. |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 84 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 19% |
| Researcher | 13 | 15% |
| Student > Master | 9 | 11% |
| Student > Bachelor | 8 | 9% |
| Student > Doctoral Student | 6 | 7% |
| Other | 13 | 15% |
| Unknown | 20 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 15 | 18% |
| Engineering | 11 | 13% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Agricultural and Biological Sciences | 5 | 6% |
| Chemical Engineering | 5 | 6% |
| Other | 8 | 9% |
| Unknown | 34 | 40% |