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Mendeley readers
| Title |
The efficacy of Cognitive training in patients with VAsCular Cognitive Impairment, No dEmentia (the Cog-VACCINE study): study protocol for a randomized controlled trial
|
|---|---|
| Published in |
Trials, August 2016
|
| DOI | 10.1186/s13063-016-1523-x |
| Pubmed ID | |
| Authors |
Yi Tang, Zude Zhu, Qing Liu, Fang Li, Jianwei Yang, Fangyu Li, Yi Xing, Jianping Jia |
| Abstract |
Vascular cognitive impairment, no dementia (VCIND) refers to cognitive deficits associated with underlying vascular causes that fall short of a dementia diagnosis. There is currently no treatment for VCIND. Computerized cognitive training, which has significantly improved cognitive function in healthy older adults and patients with cognitive impairment has not yet been applied to VCIND. The proposed study is a three-center, double-blinded, randomized controlled trial that will include 60 patients with VCIND. The patients will be randomized to either a training or a control group. The intervention is internet-based cognitive training performed for 30 min over 35 sessions. Neuropsychological assessment and functional and structural MRI will be performed before and after 7 weeks training. Primary outcomes are global cognitive function and executive function. Secondary outcome measures are neuroplasticity changes measured by functional and structural MRI. Applying an internet-based, multi-domain, adaptive program, this study aims to assess whether cognitive training improves cognitive abilities and neural plasticity in patients with subcortical VCIND. In addition to the comprehensive assessment of the participants by neuropsychological tests, cerebrovascular risk factors and apolipoprotein E genotyping, neuroplasticity will be used as an evaluation outcome in this study for, to our knowledge, the first time. The combination of functional and structural MRI and neuropsychological tests will have strong sensitivity in evaluating the effects of cognitive training and will also reveal the underlying mechanisms at work. ClinicalTrials.gov NCT02640716 . Retrospectively registered on 21 December 2015. |
Mendeley readers
The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 1% |
| Unknown | 181 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 36 | 20% |
| Student > Ph. D. Student | 25 | 14% |
| Researcher | 15 | 8% |
| Other | 9 | 5% |
| Student > Doctoral Student | 9 | 5% |
| Other | 26 | 14% |
| Unknown | 63 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 17% |
| Psychology | 28 | 15% |
| Neuroscience | 19 | 10% |
| Nursing and Health Professions | 15 | 8% |
| Sports and Recreations | 5 | 3% |
| Other | 13 | 7% |
| Unknown | 71 | 39% |