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Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

Overview of attention for article published in Molecular Neurodegeneration, June 2012
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Title
Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
Published in
Molecular Neurodegeneration, June 2012
DOI 10.1186/1750-1326-7-30
Pubmed ID
Authors

Yonghao Zhao, Yunshu Wang, Jiaye Yang, Xin Wang, Yingjun Zhao, Xian Zhang, Yun-wu Zhang

Abstract

β-site APP cleaving enzyme 1 (BACE1) cleaves β-amyloid precursor protein (APP) to initiate the production of β-amyloid (Aβ), the prime culprit in Alzheimer's disease (AD). Dysregulation of the intracellular trafficking of BACE1 may affect Aβ generation, contributing to AD pathology. In this study, we investigated whether BACE1 trafficking and BACE1-mediated APP processing/Aβ generation are affected by sorting nexin 12 (SNX12), a member of the sorting nexin (SNX) family that is involved in protein trafficking regulation.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Unknown 62 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 22%
Student > Ph. D. Student 13 21%
Student > Bachelor 8 13%
Student > Master 7 11%
Student > Doctoral Student 5 8%
Other 7 11%
Unknown 9 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 43%
Biochemistry, Genetics and Molecular Biology 10 16%
Neuroscience 5 8%
Psychology 3 5%
Engineering 2 3%
Other 3 5%
Unknown 13 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2012.
All research outputs
#20,172,971
of 22,685,926 outputs
Outputs from Molecular Neurodegeneration
#830
of 844 outputs
Outputs of similar age
#148,422
of 164,540 outputs
Outputs of similar age from Molecular Neurodegeneration
#11
of 11 outputs
Altmetric has tracked 22,685,926 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 844 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,540 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.