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Mendeley readers
Attention Score in Context
| Title |
LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease
|
|---|---|
| Published in |
Molecular Neurodegeneration, June 2012
|
| DOI | 10.1186/1750-1326-7-31 |
| Pubmed ID | |
| Authors |
Julie Brodeur, Caroline Thériault, Mélissa Lessard-Beaudoin, Alexandre Marcil, Sophie Dahan, Christine Lavoie |
| Abstract |
The Aβ peptide that accumulates in Alzheimer's disease (AD) is derived from amyloid precursor protein (APP) following proteolysis by β- and γ-secretases. Substantial evidence indicates that alterations in APP trafficking within the secretory and endocytic pathways directly impact the interaction of APP with these secretases and subsequent Aβ production. Various members of the low-density lipoprotein receptor (LDLR) family have been reported to play a role in APP trafficking and processing and are important risk factors in AD. We recently characterized a distinct member of the LDLR family called LDLR-related protein 10 (LRP10) that shuttles between the trans-Golgi Network (TGN), plasma membrane (PM), and endosomes. Here we investigated whether LRP10 participates in APP intracellular trafficking and Aβ production. |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Switzerland | 1 | 2% |
| Netherlands | 1 | 2% |
| Peru | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 59 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 20% |
| Student > Ph. D. Student | 13 | 20% |
| Student > Bachelor | 7 | 11% |
| Student > Master | 5 | 8% |
| Student > Postgraduate | 3 | 5% |
| Other | 8 | 13% |
| Unknown | 15 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 27% |
| Biochemistry, Genetics and Molecular Biology | 10 | 16% |
| Neuroscience | 6 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Chemistry | 3 | 5% |
| Other | 10 | 16% |
| Unknown | 15 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2022.
All research outputs
#2,434,998
of 22,950,943 outputs
Outputs from Molecular Neurodegeneration
#299
of 852 outputs
Outputs of similar age
#16,278
of 164,910 outputs
Outputs of similar age from Molecular Neurodegeneration
#2
of 12 outputs
Altmetric has tracked 22,950,943 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 852 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,910 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.