Title |
Pandemic influenza A virus codon usage revisited: biases, adaptation and implications for vaccine strain development
|
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Published in |
Virology Journal, November 2012
|
DOI | 10.1186/1743-422x-9-263 |
Pubmed ID | |
Authors |
Natalia Goñi, Andrés Iriarte, Victoria Comas, Martín Soñora, Pilar Moreno, Gonzalo Moratorio, Héctor Musto, Juan Cristina |
Abstract |
Influenza A virus (IAV) is a member of the family Orthomyxoviridae and contains eight segments of a single-stranded RNA genome with negative polarity. The first influenza pandemic of this century was declared in April of 2009, with the emergence of a novel H1N1 IAV strain (H1N1pdm) in Mexico and USA. Understanding the extent and causes of biases in codon usage is essential to the understanding of viral evolution. A comprehensive study to investigate the effect of selection pressure imposed by the human host on the codon usage of an emerging, pandemic IAV strain and the trends in viral codon usage involved over the pandemic time period is much needed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Peru | 1 | 25% |
United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Science communicators (journalists, bloggers, editors) | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Argentina | 1 | 2% |
Unknown | 62 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 25% |
Researcher | 12 | 19% |
Student > Bachelor | 9 | 14% |
Student > Master | 5 | 8% |
Professor > Associate Professor | 3 | 5% |
Other | 9 | 14% |
Unknown | 10 | 16% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 20 | 31% |
Biochemistry, Genetics and Molecular Biology | 10 | 16% |
Medicine and Dentistry | 7 | 11% |
Immunology and Microbiology | 5 | 8% |
Veterinary Science and Veterinary Medicine | 3 | 5% |
Other | 4 | 6% |
Unknown | 15 | 23% |