Title |
MetabR: an R script for linear model analysis of quantitative metabolomic data
|
---|---|
Published in |
BMC Research Notes, October 2012
|
DOI | 10.1186/1756-0500-5-596 |
Pubmed ID | |
Authors |
Ben Ernest, Jessica R Gooding, Shawn R Campagna, Arnold M Saxton, Brynn H Voy |
Abstract |
Metabolomics is an emerging high-throughput approach to systems biology, but data analysis tools are lacking compared to other systems level disciplines such as transcriptomics and proteomics. Metabolomic data analysis requires a normalization step to remove systematic effects of confounding variables on metabolite measurements. Current tools may not correctly normalize every metabolite when the relationships between each metabolite quantity and fixed-effect confounding variables are different, or for the effects of random-effect confounding variables. Linear mixed models, an established methodology in the microarray literature, offer a standardized and flexible approach for removing the effects of fixed- and random-effect confounding variables from metabolomic data. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 3 | 3% |
United States | 3 | 3% |
Italy | 1 | 1% |
United Kingdom | 1 | 1% |
South Africa | 1 | 1% |
Spain | 1 | 1% |
Mexico | 1 | 1% |
Unknown | 79 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 24 | 27% |
Student > Ph. D. Student | 23 | 26% |
Student > Master | 10 | 11% |
Professor > Associate Professor | 6 | 7% |
Student > Postgraduate | 5 | 6% |
Other | 15 | 17% |
Unknown | 7 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 35 | 39% |
Biochemistry, Genetics and Molecular Biology | 11 | 12% |
Chemistry | 8 | 9% |
Medicine and Dentistry | 5 | 6% |
Engineering | 4 | 4% |
Other | 15 | 17% |
Unknown | 12 | 13% |