Title |
β-catenin/Wnt signaling controls progenitor fate in the developing and regenerating zebrafish retina
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Published in |
Neural Development, August 2012
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DOI | 10.1186/1749-8104-7-30 |
Pubmed ID | |
Authors |
Jason R Meyers, Lily Hu, Ariel Moses, Kavon Kaboli, Annemarie Papandrea, Pamela A Raymond |
Abstract |
The zebrafish retina maintains two populations of stem cells: first, the germinal zone or ciliary marginal zone (CMZ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow; second, radial glia (Müller cells) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors, which are added interstitially throughout the retina with growth. Retinal injury stimulates Müller glia to dedifferentiate, re-enter the cell cycle, and generate multipotent retinal progenitors similar to those in the CMZ to replace missing neurons. The specific signals that maintain these two distinct populations of endogenous retinal stem cells are not understood. |
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