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O6-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis

Overview of attention for article published in BMC Veterinary Research, November 2012
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Title
O6-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis
Published in
BMC Veterinary Research, November 2012
DOI 10.1186/1746-6148-8-218
Pubmed ID
23140380
Authors

Gennaro Altamura, Maria Strazzullo, Annunziata Corteggio, Romina Francioso, Franco Roperto, Maurizio D'Esposito, Giuseppe Borzacchiello

Abstract

Bovine papillomaviruses (BPVs) types 1 and 2 are the only known papillomaviruses able to jump the species. In fact, BPVs 1/2 induce neoplasia in their natural bovine host but infection is also associated to neoplastic skin lesions in equids termed sarcoids. The equine sarcoid is considered to be the most common equine cutaneous tumour worldwide for which no effective therapy is available. Very little is known about the molecular mechanisms underlying tumourigenesis, although genes contributing to sarcoid development have been identified. Several studies associate the development of cancer to the loss of function of a number of oncosuppressor genes. In this study the putative role of O6-methylguanine-DNA methyltrasferase (MGMT) was investigated for sarcoids. The expression of the oncosuppressor protein was assessed in normal and sarcoid cells and tissues. In addition, the DNA methylation profile was analysed to assess the role of epigenetic mechanism in regulation of MGMT expression.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Belgium 1 3%
Unknown 32 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 18%
Other 5 15%
Student > Postgraduate 5 15%
Student > Doctoral Student 4 12%
Student > Master 4 12%
Other 6 18%
Unknown 4 12%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 15 44%
Agricultural and Biological Sciences 6 18%
Medicine and Dentistry 6 18%
Biochemistry, Genetics and Molecular Biology 2 6%
Economics, Econometrics and Finance 1 3%
Other 1 3%
Unknown 3 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2012.
All research outputs
#15,055,021
of 18,796,975 outputs
Outputs from BMC Veterinary Research
#1,630
of 2,630 outputs
Outputs of similar age
#124,677
of 164,465 outputs
Outputs of similar age from BMC Veterinary Research
#63
of 89 outputs
Altmetric has tracked 18,796,975 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,630 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,465 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.

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