Title |
Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
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Published in |
Alzheimer's Research & Therapy, October 2012
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DOI | 10.1186/alzrt146 |
Pubmed ID | |
Authors |
John M Ringman, Sally A Frautschy, Edmond Teng, Aynun N Begum, Jenny Bardens, Maryam Beigi, Karen H Gylys, Vladimir Badmaev, Dennis D Heath, Liana G Apostolova, Verna Porter, Zeba Vanek, Gad A Marshall, Gerhard Hellemann, Catherine Sugar, Donna L Masterman, Thomas J Montine, Jeffrey L Cummings, Greg M Cole |
Abstract |
Curcumin is a polyphenolic compound derived from the plant Curcuma Long Lin that has been demonstrated to have antioxidant and anti-inflammatory effects as well as effects on reducing beta-amyloid aggregation. It reduces pathology in transgenic models of Alzheimer's disease (AD) and is a promising candidate for treating human AD. The purpose of the current study is to generate tolerability and preliminary clinical and biomarker efficacy data on curcumin in persons with AD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 2 | <1% |
Australia | 2 | <1% |
Portugal | 1 | <1% |
Indonesia | 1 | <1% |
Italy | 1 | <1% |
Brazil | 1 | <1% |
Israel | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 355 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 59 | 16% |
Student > Master | 50 | 14% |
Student > Ph. D. Student | 48 | 13% |
Researcher | 41 | 11% |
Student > Doctoral Student | 19 | 5% |
Other | 64 | 18% |
Unknown | 84 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 57 | 16% |
Agricultural and Biological Sciences | 47 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 39 | 11% |
Biochemistry, Genetics and Molecular Biology | 25 | 7% |
Neuroscience | 25 | 7% |
Other | 72 | 20% |
Unknown | 100 | 27% |