Title |
Evaluation of function predictions by PFP, ESG, and PSI-BLAST for moonlighting proteins
|
---|---|
Published in |
BMC Proceedings, November 2012
|
DOI | 10.1186/1753-6561-6-s7-s5 |
Pubmed ID | |
Authors |
Ishita K Khan, Meghana Chitale, Catherine Rayon, Daisuke Kihara |
Abstract |
Advancements in function prediction algorithms are enabling large scale computational annotation for newly sequenced genomes. With the increase in the number of functionally well characterized proteins it has been observed that there are many proteins involved in more than one function. These proteins characterized as moonlighting proteins show varied functional behavior depending on the cell type, localization in the cell, oligomerization, multiple binding sites, etc. The functional diversity shown by moonlighting proteins may have significant impact on the traditional sequence based function prediction methods. Here we investigate how well diverse functions of moonlighting proteins can be predicted by some existing function prediction methods. |
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